Comparative Study of OLP and OLL: Demographic and Clinical Profile in a Reference Center in Brazil.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral diseases Pub Date : 2025-01-06 DOI:10.1111/odi.15247

Thales Felipe Dos Santos de Oliveira, Michelle Roxo Gonçalves, Marco Antonio Trevizani Martins, Manoela Domingues Martins, Lorenzo Lo Muzio, Fernanda Visioli, Vinicius Coelho Carrard

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引用次数: 0

Abstract

Objective: To compare the demographic and clinical profiles of oral lichen planus (OLP) and oral lichenoid lesions (OLL) diagnosed at a reference center in Southern Brazil from 2010 to 2019.

Methods: This retrospective study included 117 cases of suspected OLP submitted for biopsy. Investigated variables comprised sociodemographic profiles, medical history, harmful habits, clinical characteristics, and histopathological features. Categorical and numerical variables were analyzed using chi-square and Mann-Whitney tests (p < 0.01), respectively.

Results: Applying strict diagnostic criteria, 29% (n = 34) of cases were classified as OLP and 71% (n = 83) as OLL. OLP cases had mainly multifocal manifestations (82.4%), exhibiting a reticular pattern (100%) and primarily occurring on the buccal mucosa (94.1%). Conversely, OLL cases presented both unilateral (48.2%) and multifocal (51.8%) distributions, with a predominantly atrophic-erosive pattern (77.1%) and higher occurrence on the buccal mucosa (69.9%) and tongue (48.2%). OLL patients reported a higher frequency of systemic disorders and medication use (p < 0.01). Hypertension was the most prevalent condition, leading to the frequent use of cardiovascular medications. Two OLL cases without initial dysplasia underwent malignant transformation.

Conclusion: Patient profiles and clinical manifestations of the entities were similar, highlighting the utility of a differential diagnosis, particularly given the apparent association between malignant transformation and OLL cases.

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OLP和OLL的比较研究：巴西某参考中心的人口统计学和临床概况。

目的：比较2010年至2019年在巴西南部某参考中心诊断的口腔扁平苔藓（OLP）和口腔苔藓样病变（OLL）的人口学和临床特征。方法：回顾性研究117例经活检的疑似OLP患者。调查的变量包括社会人口统计资料、病史、不良习惯、临床特征和组织病理学特征。采用卡方检验和Mann-Whitney检验对分类变量和数值变量进行分析(p)。结果：应用严格的诊断标准，29% （n = 34）的病例被归为OLP， 71% （n = 83）的病例被归为OLL。OLP主要表现为多灶性（82.4%），网状（100%），主要发生在颊黏膜（94.1%）。相反，OLL病例表现为单侧（48.2%）和多灶（51.8%）分布，以萎缩糜烂型为主（77.1%），颊黏膜（69.9%）和舌部（48.2%）发生率较高。OLL患者报告全身性疾病和药物使用的频率更高(p结论：患者概况和实体的临床表现相似，突出了鉴别诊断的实用性，特别是考虑到恶性转化和OLL病例之间的明显关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.