Is There a Correlation Between Quality of Life and Salivary Interleukin-6 in Patients With Oral Lichen Planus or Burning Mouth Syndrome?

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral diseases Pub Date : 2025-01-06 DOI:10.1111/odi.15249

Ana Glavina, Liborija Lugović-Mihić, Dinko Martinović, Livia Cigić, Dolores Biočina-Lukenda, Daniela Šupe-Domić

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引用次数: 0

Abstract

Objectives: The aim of our study was to compare the salivary interleukin-6 (IL-6) concentration and the quality of life (QoL) in patients with oral lichen planus (OLP) or burning mouth syndrome (BMS).

Materials and methods: A total of 160 subjects participated in the cross-sectional study. The unstimulated whole saliva (UWS) was used as a reference for the determination of salivary IL-6 concentration by enzyme-linked immunosorbent assays (ELISAs). QoL was assessed using the Croatian version of the Oral Health Impact Profile Questionnaire (OHIP-CRO14).

Results: The salivary IL-6 concentration showed no statistically significant difference between patients with OLP, patients with BMS or control subjects (p = 0.244). There was a strong/good positive correlation between symptom intensity (pain/burning) and the OHIP-CRO14 dimension "physical pain" (r = 0.720, p < 0.001) and "physical impossibility" (r = 0.372, p = 0.003) in patients with OLP. There was a good positive correlation between symptom intensity (pain/burning) and the OHIP-CRO14 dimension "handicap" (r = 0.353, p = 0.005) in patients with BMS.

Conclusions: Symptom intensity (pain/burning) showed no correlation with salivary IL-6 concentration in patients with OLP or BMS. A slight increase or decrease in salivary IL-6 concentration in OLP or BMS indicates an inflammatory etiopathogenesis of OLP and a loss of neuroprotection in BMS.

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.