Enhanced Tolerability and Improved Outcomes in Acne Management: A Real-World Study of Dermocosmetic Adjunctive Therapy

IF 2.3 4区医学 Q2 DERMATOLOGY

Journal of Cosmetic Dermatology Pub Date : 2025-01-06 DOI:10.1111/jocd.16772

Dong Hye Suh, Tae-Eun Kim, Sang Jun Lee, Su Jin Jeong, Eunsun Baek, Min Kyung Shin

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引用次数: 0

Abstract

Background

Topical retinoids, while renowned for their efficacy in treating acne vulgaris, are often hampered by inter-individual variability in tolerability. This challenge, primarily driven by side effects like erythema, scaling, and dryness, significantly impacts patient adherence and, ultimately, treatment outcomes.

Aims

This prospective, multi-center, observational study investigated the novel role of a specific dermocosmetic regimen as adjunctive therapy, focusing on its ability to mitigate retinoid-induced side effects and enhance the overall tolerability of acne treatment regimens in a Korean population.

Patients and Methods

We enrolled 304 patients receiving conventional acne therapies and integrated a standardized dermocosmetic regimen (foaming facial wash and moisturizer) for 12 weeks. Our primary endpoint assessed changes in skin sensitivity scores in both retinoid and non-retinoid users. We incorporated a patient-reported outcome measure evaluating acne's impact on quality of life across different facial areas as a secondary endpoint.

Results

Our results revealed a significant improvement in skin sensitivity across both patient groups, effectively mitigating the anticipated heightened sensitivity in retinoid users. This finding suggests that dermocosmetics may hold the key to unlocking consistent, age-independent tolerance to retinoid therapy. Furthermore, we observed a compelling correlation between improvements in cheek acne and enhanced quality of life, highlighting the profound psychological impact of this specific facial area.

Conclusions

This study pioneers a new understanding of holistic acne management, emphasizing the synergistic potential of dermocosmetics in enhancing treatment adherence, improving long-term outcomes, and ultimately transforming patients' lives.

Abstract Image

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增强耐受性和改善痤疮管理的结果：皮肤美容辅助治疗的现实世界研究。

背景：局部类维生素a虽然以其治疗寻常性痤疮的疗效而闻名，但往往受到个体间耐受性差异的阻碍。这一挑战主要是由红斑、脱屑和干燥等副作用引起的，严重影响了患者的依从性，并最终影响了治疗结果。目的：这项前瞻性、多中心、观察性研究调查了一种特殊的皮肤美容方案作为辅助治疗的新作用，重点关注其减轻类维生素a诱导的副作用和提高韩国人群对痤疮治疗方案的总体耐受性的能力。患者和方法：我们招募了304名接受常规痤疮治疗的患者，并整合了标准化的皮肤美容方案（泡沫洗面奶和保湿霜），为期12周。我们的主要终点评估了类维甲酸和非类维甲酸使用者皮肤敏感性评分的变化。我们将患者报告的结果测量纳入评估痤疮对不同面部区域生活质量的影响作为次要终点。结果：我们的研究结果显示，两组患者的皮肤敏感性都有显著改善，有效地减轻了类维生素a使用者预期的高度敏感性。这一发现表明，皮肤化妆品可能是开启对类维生素a治疗持续的、与年龄无关的耐受性的关键。此外，我们观察到脸颊痤疮的改善与生活质量的提高之间存在令人信服的相关性，强调了这一特定面部区域的深刻心理影响。结论：本研究开创了对痤疮整体治疗的新认识，强调了真皮化妆品在增强治疗依从性、改善长期疗效并最终改变患者生活方面的协同潜力。

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来源期刊

Journal of Cosmetic Dermatology DERMATOLOGY-

CiteScore

4.30

自引率

13.00%

发文量

818

审稿时长

>12 weeks

期刊介绍： The Journal of Cosmetic Dermatology publishes high quality, peer-reviewed articles on all aspects of cosmetic dermatology with the aim to foster the highest standards of patient care in cosmetic dermatology. Published quarterly, the Journal of Cosmetic Dermatology facilitates continuing professional development and provides a forum for the exchange of scientific research and innovative techniques. The scope of coverage includes, but will not be limited to: healthy skin; skin maintenance; ageing skin; photodamage and photoprotection; rejuvenation; biochemistry, endocrinology and neuroimmunology of healthy skin; imaging; skin measurement; quality of life; skin types; sensitive skin; rosacea and acne; sebum; sweat; fat; phlebology; hair conservation, restoration and removal; nails and nail surgery; pigment; psychological and medicolegal issues; retinoids; cosmetic chemistry; dermopharmacy; cosmeceuticals; toiletries; striae; cellulite; cosmetic dermatological surgery; blepharoplasty; liposuction; surgical complications; botulinum; fillers, peels and dermabrasion; local and tumescent anaesthesia; electrosurgery; lasers, including laser physics, laser research and safety, vascular lasers, pigment lasers, hair removal lasers, tattoo removal lasers, resurfacing lasers, dermal remodelling lasers and laser complications.