A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of a Nutraceutical Supplement With Standardized Botanicals in Males With Thinning Hair

IF 2.3 4区医学 Q2 DERMATOLOGY

Journal of Cosmetic Dermatology Pub Date : 2025-01-06 DOI:10.1111/jocd.16778

Neal Bhatia, Glynis Ablon, Patricia K. Farris, Adina Hazan, Isabelle Raymond

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引用次数: 0

Abstract

Background

Hair thinning in men is a prevalent issue for which treatment oftentimes consists of a multi-modal approach. Targeting key root causes of hair thinning, such as hormones, stress, and metabolism through vitamins, minerals, and botanicals, has been shown to be effective in improving hair growth and quality in women. This approach could also be effective in improving hair growth and quality in men with thinning hair.

Aims

This study investigates the safety and efficacy of a nutraceutical in improving hair growth and quality in men with thinning hair.

Methods

This was a 6-month multi-center, double-blind, randomized, placebo-controlled trial. Men aged 21–61 years old with confirmed hair thinning were included. Subjects were randomized to receive the oral supplement or placebo. The study end points included changes in blinded Global Investigator Ratings for hair growth and quality, the Men's Hair Growth Questionnaire (MHGQ), and changes in the Arizona Sexual Experience Scale (ASEX) in the active group compared to baseline and placebo.

Results

Daily intake of the nutraceutical resulted in significantly more subjects in the active group compared to the placebo rated as improved for hair growth and quality in the blinded investigator global assessments. Overall changes and responses to the MHGQ also corroborated blinded investigator ratings. There were no trends in either treatment group for changes in sexual function on the ASEX questionnaire, and the supplement was well tolerated.

Conclusions

Ingestion of a nutraceutical targeting key root causes of male hair thinning significantly improves hair growth and quality in men with no changes in sexual function.

Abstract Image

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一项随机、双盲、安慰剂对照的研究，旨在评估一种含有标准化植物成分的营养补充剂对头发稀疏的男性的安全性和有效性。

背景：男性头发稀疏是一个普遍的问题，治疗通常包括多模式的方法。针对头发稀疏的关键根源，如激素、压力和通过维生素、矿物质和植物药物进行新陈代谢，已被证明对改善女性头发的生长和质量是有效的。这种方法也可以有效地改善头发稀疏的男性的头发生长和质量。目的：本研究探讨了一种营养保健品在改善头发稀疏男性头发生长和质量方面的安全性和有效性。方法：这是一项为期6个月的多中心、双盲、随机、安慰剂对照试验。年龄在21-61岁之间且确认头发稀疏的男性被纳入研究对象。受试者随机接受口服补充剂或安慰剂。研究终点包括与基线和安慰剂相比，活跃组中头发生长和质量的盲法全球研究者评分、男性头发生长问卷（MHGQ）和亚利桑那性体验量表（ASEX）的变化。结果：在盲法研究者全球评估中，与安慰剂相比，每日摄入营养保健品的活性组中有更多的受试者被评为改善了头发生长和质量。MHGQ的总体变化和反应也证实了盲法研究者的评分。在ASEX问卷调查中，两个治疗组都没有出现性功能变化的趋势，而且这种补充剂耐受性良好。结论：摄入一种针对男性头发稀疏的主要根本原因的营养保健品可显著改善男性的头发生长和质量，而性功能没有变化。

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来源期刊

Journal of Cosmetic Dermatology DERMATOLOGY-

CiteScore

4.30

自引率

13.00%

发文量

818

审稿时长

>12 weeks

期刊介绍： The Journal of Cosmetic Dermatology publishes high quality, peer-reviewed articles on all aspects of cosmetic dermatology with the aim to foster the highest standards of patient care in cosmetic dermatology. Published quarterly, the Journal of Cosmetic Dermatology facilitates continuing professional development and provides a forum for the exchange of scientific research and innovative techniques. The scope of coverage includes, but will not be limited to: healthy skin; skin maintenance; ageing skin; photodamage and photoprotection; rejuvenation; biochemistry, endocrinology and neuroimmunology of healthy skin; imaging; skin measurement; quality of life; skin types; sensitive skin; rosacea and acne; sebum; sweat; fat; phlebology; hair conservation, restoration and removal; nails and nail surgery; pigment; psychological and medicolegal issues; retinoids; cosmetic chemistry; dermopharmacy; cosmeceuticals; toiletries; striae; cellulite; cosmetic dermatological surgery; blepharoplasty; liposuction; surgical complications; botulinum; fillers, peels and dermabrasion; local and tumescent anaesthesia; electrosurgery; lasers, including laser physics, laser research and safety, vascular lasers, pigment lasers, hair removal lasers, tattoo removal lasers, resurfacing lasers, dermal remodelling lasers and laser complications.