A stress paradox: the dual role of the unfolded protein response in the placenta.

IF 3.9 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Frontiers in Endocrinology Pub Date : 2024-12-20 eCollection Date: 2024-01-01 DOI:10.3389/fendo.2024.1525189
Diba Chowdhury, Chloe E Jang, Patrick Lajoie, Stephen J Renaud
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引用次数: 0

Abstract

The placenta is a temporary organ that forms during pregnancy and is essential for fetal development and maternal health. As an endocrine organ, proper placental function requires continual production, folding, and transport of proteins and lipids. Central to these processes is the endoplasmic reticulum (ER), a dynamic organelle responsible for maintaining cellular protein and lipid synthesis and processing. ER stress occurs when there is an accumulation of unfolded or misfolded proteins, which triggers the activation of cellular pathways collectively called the unfolded protein response. Unfolded protein response pathways act to alleviate the misfolded protein burden and restore ER homeostasis, or if unresolved, initiate cell death. While prolonged ER stress has been linked to deficient placental function and adverse pregnancy outcomes, basal activation of unfolded protein response pathways is required for placental development and function. This review explores the importance of ER homeostasis in placental development and function, examining how disruptions in ER stress responses may contribute to adverse pregnancy outcomes.

应激悖论:未折叠蛋白反应在胎盘中的双重作用。
胎盘是怀孕期间形成的临时器官,对胎儿发育和母亲健康至关重要。作为一个内分泌器官,正常的胎盘功能需要持续的蛋白质和脂质的产生、折叠和运输。这些过程的中心是内质网(ER),一个负责维持细胞蛋白质和脂质合成和加工的动态细胞器。当未折叠或错误折叠的蛋白质积累时,内质网应激就会发生,这会触发细胞通路的激活,统称为未折叠蛋白质反应。未折叠的蛋白质反应途径可以减轻错误折叠的蛋白质负担并恢复内质网稳态,或者如果未解决,则启动细胞死亡。虽然长期内质网应激与胎盘功能缺陷和不良妊娠结局有关,但未折叠蛋白反应途径的基础激活是胎盘发育和功能所必需的。这篇综述探讨了内质网稳态在胎盘发育和功能中的重要性,研究了内质网应激反应的破坏如何导致不良妊娠结局。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Frontiers in Endocrinology
Frontiers in Endocrinology Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
5.70
自引率
9.60%
发文量
3023
审稿时长
14 weeks
期刊介绍: Frontiers in Endocrinology is a field journal of the "Frontiers in" journal series. In today’s world, endocrinology is becoming increasingly important as it underlies many of the challenges societies face - from obesity and diabetes to reproduction, population control and aging. Endocrinology covers a broad field from basic molecular and cellular communication through to clinical care and some of the most crucial public health issues. The journal, thus, welcomes outstanding contributions in any domain of endocrinology. Frontiers in Endocrinology publishes articles on the most outstanding discoveries across a wide research spectrum of Endocrinology. The mission of Frontiers in Endocrinology is to bring all relevant Endocrinology areas together on a single platform.
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