Xiaolian Xing, Hongwei Liu, Minheng Zhang, Yang Li
{"title":"Mapping the current trends and hotspots of extracellular vesicles in Alzheimer's disease: a bibliometric analysis.","authors":"Xiaolian Xing, Hongwei Liu, Minheng Zhang, Yang Li","doi":"10.3389/fnagi.2024.1485750","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Extracellular vesicles (EVs) have garnered significant attention in Alzheimer's disease (AD) research over the past decade, largely due to their potential in diagnostics and therapeutics. Although the investigation of EVs in AD is a relatively recent endeavor, a comprehensive bibliometric analysis of this rapidly growing field has yet to be conducted.</p><p><strong>Methods: </strong>This study aims to elucidate and synthesize the relationship between EVs and AD, offering critical insights to guide future research and expand therapeutic possibilities. Over the past 10-15 years, substantial progress has been made in this domain. Through bibliometric techniques, this analysis assesses research performance by examining scientific publications and metrics, including productivity indicators, impact measurements, data mining, and visualization tools.</p><p><strong>Results: </strong>A total of 602 publications were analyzed using various online platforms for bibliometric analysis. Notably, the number of publications began to increase rapidly in 2018, with China and the United States emerging as leaders in this research area. The National Institute on Aging produced the highest number of publications among institutions. The <i>Journal of Molecular Sciences</i> and the <i>Journal of Biological Chemistry</i> were the most prolific and most frequently cited journals, respectively. Among individual contributors, Dimitrios Kapogiannis was identified as the most productive author, while Edward J. Goetzl was the most co-cited. The most prevalent keywords included \"neurodegenerative diseases,\" \"exosomes,\" \"blood biomarkers,\" \"amyloid beta,\" \"microglia,\" and \"tau protein.\" Current research hotspots involve microRNA dysregulation, oxidative stress, carboxyl-terminal fragments, small EVs, and mesenchymal stem cell-derived EVs, indicating key areas for future research.</p><p><strong>Conclusion: </strong>Research on microRNA dysregulation, oxidative stress, carboxyl-terminal fragments, small EVs, and mesenchymal stem cell-derived EVs represents a critical frontier in the study of Alzheimer's disease. The role of EV-mediated neuroinflammation in AD is a focal point of ongoing investigation and will likely shape future developments in the field.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"16 ","pages":"1485750"},"PeriodicalIF":4.1000,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11697149/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Aging Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fnagi.2024.1485750","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Extracellular vesicles (EVs) have garnered significant attention in Alzheimer's disease (AD) research over the past decade, largely due to their potential in diagnostics and therapeutics. Although the investigation of EVs in AD is a relatively recent endeavor, a comprehensive bibliometric analysis of this rapidly growing field has yet to be conducted.
Methods: This study aims to elucidate and synthesize the relationship between EVs and AD, offering critical insights to guide future research and expand therapeutic possibilities. Over the past 10-15 years, substantial progress has been made in this domain. Through bibliometric techniques, this analysis assesses research performance by examining scientific publications and metrics, including productivity indicators, impact measurements, data mining, and visualization tools.
Results: A total of 602 publications were analyzed using various online platforms for bibliometric analysis. Notably, the number of publications began to increase rapidly in 2018, with China and the United States emerging as leaders in this research area. The National Institute on Aging produced the highest number of publications among institutions. The Journal of Molecular Sciences and the Journal of Biological Chemistry were the most prolific and most frequently cited journals, respectively. Among individual contributors, Dimitrios Kapogiannis was identified as the most productive author, while Edward J. Goetzl was the most co-cited. The most prevalent keywords included "neurodegenerative diseases," "exosomes," "blood biomarkers," "amyloid beta," "microglia," and "tau protein." Current research hotspots involve microRNA dysregulation, oxidative stress, carboxyl-terminal fragments, small EVs, and mesenchymal stem cell-derived EVs, indicating key areas for future research.
Conclusion: Research on microRNA dysregulation, oxidative stress, carboxyl-terminal fragments, small EVs, and mesenchymal stem cell-derived EVs represents a critical frontier in the study of Alzheimer's disease. The role of EV-mediated neuroinflammation in AD is a focal point of ongoing investigation and will likely shape future developments in the field.
背景：在过去的十年中，细胞外囊泡（EVs）在阿尔茨海默病（AD）的研究中引起了极大的关注，主要是由于它们在诊断和治疗方面的潜力。尽管对AD中ev的调查是一个相对较新的尝试，但对这一快速增长的领域尚未进行全面的文献计量分析。方法：本研究旨在阐明和综合EVs与AD之间的关系，为指导未来的研究和扩大治疗可能性提供重要见解。在过去10-15年中，这一领域取得了实质性进展。通过文献计量学技术，该分析通过检查科学出版物和指标（包括生产力指标、影响测量、数据挖掘和可视化工具）来评估研究绩效。结果：使用各种在线平台进行文献计量分析，共分析了602份出版物。值得注意的是，2018年发表的论文数量开始迅速增加，中国和美国在这一研究领域处于领先地位。在所有机构中，国家老龄问题研究所发表的出版物数量最多。《分子科学杂志》（Journal of Molecular Sciences）和《生物化学杂志》（Journal of Biological Chemistry）分别是最多产和最常被引用的期刊。在个人贡献者中，Dimitrios Kapogiannis被认为是最多产的作者，而Edward J. Goetzl是被共同引用最多的作者。最流行的关键词包括“神经退行性疾病”、“外泌体”、“血液生物标志物”、“淀粉样蛋白”、“小胶质细胞”和“tau蛋白”。目前的研究热点包括microRNA失调、氧化应激、羧基末端片段、小ev、间充质干细胞衍生ev等，是未来研究的重点领域。结论：研究microRNA失调、氧化应激、羧基末端片段、小ev和间充质干细胞衍生ev是阿尔茨海默病研究的关键前沿。ev介导的神经炎症在AD中的作用是正在进行的研究的焦点，并可能影响该领域的未来发展。
期刊介绍：
Frontiers in Aging Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the mechanisms of Central Nervous System aging and age-related neural diseases. Specialty Chief Editor Thomas Wisniewski at the New York University School of Medicine is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
