The protective role of baicalin regulation of autophagy in cancers.

IF 2 4区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Cytotechnology Pub Date : 2025-02-01 Epub Date: 2025-01-03 DOI:10.1007/s10616-024-00689-0
Qi Zhang, Shiyun Guo, Hangwei Ge, Honggang Wang
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引用次数: 0

Abstract

Autophagy is a conservative process of self degradation, in which abnormal organelles, proteins and other macromolecules are encapsulated and transferred to lysosomes for subsequent degradation. It maintains the intracellular balance, and responds to cellular conditions such as hunger or stress. To date, there are mainly three types of autophagy: macroautophagy, microautophagy and chaperone-mediated autophagy. Autophagy plays a key role in regulating multiple physiological and pathological processes, such as cell metabolism, development, energy homeostasis, cell death and hunger adaptation, and so on. Increasing evidence indicates that autophagy dysfunction participates in many kinds of cancers, such as liver cancer, pancreatic cancer, prostate cancer, and so on. However, the relevant mechanisms are not yet fully understood. Baicalin is a natural flavonoid compound extracted from the traditional Chinese medicine Scutellaria baicalensis. The research has shown that after oral or intravenous administration of baicalin, it is delivered to various organs through the systemic circulation, with the highest volume in the kidneys and lungs. More and more evidence suggests that baicalin has antioxidant, anticancer, anti-inflammatory, anti-apoptotic, immunomodulatory and antiviral effects. Therefore, baicalin plays an important role in various diseases, such as cancers, lung diseases, liver diseases, cardiovascular diseases, ans so on. However, the relevant mechanisms have not yet been fully clear. Recently, increasing evidence indicates that baicalin participates in different cancer by regulating autophagy. Herein, we reviewed the current knowledge about the role and mechanism of baicalin regulation of autophagy in multiple types of cancers to lay the theoretical foundation for future related researches.

黄芩苷调节肿瘤细胞自噬的保护作用。
自噬是一种保守的自我降解过程,在这一过程中,异常细胞器、蛋白质和其他大分子被包裹起来,并转移到溶酶体进行后续降解。它能维持细胞内的平衡,并对饥饿或压力等细胞状况做出反应。迄今为止,自噬主要有三种类型:大自噬、微自噬和伴侣介导的自噬。自噬在调节细胞代谢、发育、能量平衡、细胞死亡和饥饿适应等多种生理和病理过程中发挥着关键作用。越来越多的证据表明,自噬功能障碍参与了多种癌症的发生,如肝癌、胰腺癌、前列腺癌等。然而,相关机制尚未完全明了。黄芩苷是从传统中药黄芩中提取的一种天然黄酮类化合物。研究表明,口服或静脉注射黄芩苷后,黄芩苷会通过全身循环输送到各个器官,其中肾脏和肺部的含量最高。越来越多的证据表明,黄芩苷具有抗氧化、抗癌、抗炎、抗细胞凋亡、免疫调节和抗病毒等作用。因此,黄芩苷在癌症、肺病、肝病、心血管疾病等多种疾病中发挥着重要作用。然而,相关机制尚未完全明确。最近,越来越多的证据表明,黄芩苷通过调节自噬参与不同癌症的发生。在此,我们综述了黄芩苷调控自噬在多种癌症中的作用和机制,为今后的相关研究奠定理论基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cytotechnology
Cytotechnology 生物-生物工程与应用微生物
CiteScore
4.10
自引率
0.00%
发文量
49
审稿时长
6-12 weeks
期刊介绍: The scope of the Journal includes: 1. The derivation, genetic modification and characterization of cell lines, genetic and phenotypic regulation, control of cellular metabolism, cell physiology and biochemistry related to cell function, performance and expression of cell products. 2. Cell culture techniques, substrates, environmental requirements and optimization, cloning, hybridization and molecular biology, including genomic and proteomic tools. 3. Cell culture systems, processes, reactors, scale-up, and industrial production. Descriptions of the design or construction of equipment, media or quality control procedures, that are ancillary to cellular research. 4. The application of animal/human cells in research in the field of stem cell research including maintenance of stemness, differentiation, genetics, and senescence, cancer research, research in immunology, as well as applications in tissue engineering and gene therapy. 5. The use of cell cultures as a substrate for bioassays, biomedical applications and in particular as a replacement for animal models.
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