Establishing the reference intervals of plasma PLG, FXII activity, and FXIII antigen in healthy adults in Guangzhou.

IF 2 3区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

BMC Cardiovascular Disorders Pub Date : 2025-01-06 DOI:10.1186/s12872-024-04398-6

Zhenfei Zhang, Fang Wu, Zejie Zhou, Huixian Luo, Yuehua Qin, Meng Yang, Yinjuan Mo, Zhiqiang Zhu, Yi Zhang, Yonghui Guo

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引用次数: 0

Abstract

Objective: To establish the reference intervals of plasma Plasminogen, Factor XII activity, and Factor XIII Antigen in healthy adults in Guangzhou.

Methods: A total of 168 young people (75 males and 93 females, aged 18-65 years) who underwent physical examination in Zhujiang Hospital of Southern Medical University from 2020 to 2022 were recruited. Sysmex CS5100 automatic coagulation analyzer and matching reagents were used to detect Plasminogen. Factor XII activity and Factor XIII Antigen were detected using the ACL TOP 700 (Instrumentation Laboratory, Bedford, MA, USA) automatic coagulation analyzer and matching reagents; reference intervals were established.

Results: Plasma Plasminogen and Factor XIII Antigen were normally distributed, and plasma Factor XII activity showed a skewed distribution with no statistical significance in gender. The established reference intervals were as follows: Plasminogen: 71.6-123.0%; Factor XIII Antigen: 55.1-113.1%; Factor XII: 42.3-144.1%.

Conclusion: The reference intervals for special coagulation items of the laboratory population in a particular area should be established to provide results that align with the population characteristics for assessing the coagulation status of clinical patients.

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广州市健康成人血浆PLG、FXII活性及FXIII抗原参考区间的建立

目的：建立广州地区健康成人血浆纤溶酶原、XII因子活性及XIII因子抗原的参考区间。方法：招募2020 - 2022年在南方医科大学珠江医院体检的青年168人（男75人，女93人，年龄18-65岁）。采用Sysmex CS5100全自动凝血仪及配套试剂检测纤溶酶原。采用ACL TOP 700 （instruments Laboratory, Bedford， MA， USA）自动凝血分析仪及配套试剂检测因子XII活性和因子XIII抗原；建立参考区间。结果：血浆纤溶酶原和XIII因子抗原呈正态分布，血浆XII因子活性呈偏态分布，性别差异无统计学意义。建立的参考区间为：纤溶酶原：71.6 ~ 123.0%；因子十三抗原：55.1-113.1%；因子十二：42.3-144.1%。结论：建立特定地区实验室人群特殊凝血项目的参考区间，提供符合人群特点的结果，以评估临床患者凝血状况。

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来源期刊

BMC Cardiovascular Disorders CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

3.50

自引率

0.00%

发文量

480

审稿时长

1 months

期刊介绍： BMC Cardiovascular Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of disorders of the heart and circulatory system, as well as related molecular and cell biology, genetics, pathophysiology, epidemiology, and controlled trials.