The multi-faceted roles of cancer-associated fibroblasts in pancreatic cancer

IF 4.4 2区生物学 Q2 CELL BIOLOGY

Cellular signalling Pub Date : 2025-01-03 DOI:10.1016/j.cellsig.2024.111584

John Y. Kwon, Renzo E. Vera, Martin E. Fernandez-Zapico

引用次数: 0

Abstract

The tumor microenvironment (TME) has been linked with the pathogenesis of pancreatic ductal adenocarcinoma (PDAC), the most common histological subtype of pancreatic cancer. A central component of the TME are cancer-associated fibroblasts (CAFs), which can either suppress or promote tumor growth in a context-dependent manner. In this review, we will discuss the multi-faceted roles of CAFs in tumor-stroma interactions influencing cancer initiation, progression and therapeutic response.

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癌症相关成纤维细胞在胰腺癌中的多重作用。

肿瘤微环境（TME）与胰腺导管腺癌（PDAC）的发病机制有关，PDAC是胰腺癌最常见的组织学亚型。TME的一个核心组成部分是癌症相关成纤维细胞（CAFs），它可以以一种依赖于环境的方式抑制或促进肿瘤生长。在这篇综述中，我们将讨论CAFs在影响癌症发生、进展和治疗反应的肿瘤-基质相互作用中的多方面作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cellular signalling 生物-细胞生物学

CiteScore

8.40

自引率

0.00%

发文量

250

审稿时长

27 days

期刊介绍： Cellular Signalling publishes original research describing fundamental and clinical findings on the mechanisms, actions and structural components of cellular signalling systems in vitro and in vivo. Cellular Signalling aims at full length research papers defining signalling systems ranging from microorganisms to cells, tissues and higher organisms.