Fluid–structure–growth modeling in ascending aortic aneurysm: capability to reproduce a patient case

IF 3 3区医学 Q2 BIOPHYSICS

Biomechanics and Modeling in Mechanobiology Pub Date : 2025-01-06 DOI:10.1007/s10237-024-01915-6

Kexin Yan, Wenfeng Ye, Antonio Martínez, Leonardo Geronzi, Pierre Escrig, Jacques Tomasi, Michel Rochette, Pascal Haigron, Aline Bel-Brunon

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引用次数: 0

Abstract

Predicting the evolution of ascending aortic aneurysm (AscAA) growth is a challenge, complicated by the intricate interplay of aortic geometry, tissue behavior, and blood flow dynamics. We investigate a flow-structural growth and remodeling (FSG) model based on the homogenized constrained mixture theory to simulate realistic AscAA growth evolution. Our approach involves initiating a finite element model with an initial elastin insult, driven by the distribution of Time-Averaged Wall Shear Stress (TAWSS) derived from computational fluid dynamics simulations. Through FSG simulation, we first calibrate the growth and remodeling material parameters to reproduce the growth observed on a patient-specific case. Then, we explore the influence of two critical parameters: the direction of the inlet jet flow, which affects the zone of significant TAWSS, and prestretch, which impacts the tissue homeostatic state. Our results show that calibrating material parameters, inlet flow direction, and prestretch allows to reproduce the observed growth, and that prestretch calibration and inlet flow direction significantly influence the simulated growth pattern. Our workflow can be applied to additional patient cases to confirm these tendencies and progress toward a predictive tool for clinical decision support.

查看原文本刊更多论文

升主动脉瘤的流体结构-生长模型：重现患者病例的能力。

预测升主动脉瘤（AscAA）生长的演变是一个挑战，由于主动脉几何形状、组织行为和血流动力学的复杂相互作用而变得复杂。研究了基于均质约束混合理论的流-结构生长与重塑（FSG）模型，以模拟真实的AscAA生长演化过程。我们的方法包括启动一个具有初始弹性蛋白损伤的有限元模型，该模型由计算流体动力学模拟得出的时间平均壁面剪切应力（TAWSS）分布驱动。通过FSG模拟，我们首先校准生长和重塑材料参数，以重现在特定病例中观察到的生长。然后，我们探讨了两个关键参数的影响：影响TAWSS显著区域的进口射流方向和影响组织稳态状态的预拉伸。我们的研究结果表明，校准材料参数、进口流动方向和预拉伸可以重现观察到的生长，并且预拉伸校准和进口流动方向显著影响模拟的生长模式。我们的工作流程可以应用于其他患者病例，以确认这些趋势，并朝着临床决策支持的预测工具发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomechanics and Modeling in Mechanobiology 工程技术-工程：生物医学

CiteScore

7.10

自引率

8.60%

发文量

119

审稿时长

6 months

期刊介绍： Mechanics regulates biological processes at the molecular, cellular, tissue, organ, and organism levels. A goal of this journal is to promote basic and applied research that integrates the expanding knowledge-bases in the allied fields of biomechanics and mechanobiology. Approaches may be experimental, theoretical, or computational; they may address phenomena at the nano, micro, or macrolevels. Of particular interest are investigations that (1) quantify the mechanical environment in which cells and matrix function in health, disease, or injury, (2) identify and quantify mechanosensitive responses and their mechanisms, (3) detail inter-relations between mechanics and biological processes such as growth, remodeling, adaptation, and repair, and (4) report discoveries that advance therapeutic and diagnostic procedures. Especially encouraged are analytical and computational models based on solid mechanics, fluid mechanics, or thermomechanics, and their interactions; also encouraged are reports of new experimental methods that expand measurement capabilities and new mathematical methods that facilitate analysis.