Gas and vapor phase detection of chemical threats on cooled SERS substrates.

IF 5.6 1区化学 Q1 CHEMISTRY, ANALYTICAL

Talanta Pub Date : 2025-05-01 Epub Date: 2024-12-26 DOI:10.1016/j.talanta.2024.127479

Aron Hakonen, Tomas Rindzevicius, Damir Asoli, Johan Engelbrektsson, Max Bäckman, Nora Molander, Per Ola Andersson, Anja Boisen

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引用次数: 0

Abstract

Detection of airborne chemical threats is an emerging challenge amidst the prevailing tumultuous global milieu. Extensive investigation has showcased the substantial promise of surface-enhanced Raman spectroscopy (SERS) for the on-site identification of hazardous chemicals present in liquid mediums, whether directly from a fluid source or through methodologies such as swab sampling. Nonetheless, exploration into the applicability of SERS for the detection of gas or vapor-phase chemical threats remains severely constrained. In this study, we present the successful realization of sub-parts per million (ppm) detection thresholds via SERS for hydrogen cyanide (HCN) and Tabun (GA) chemical warfare agents, facilitated by a custom-made gas sampling cell integrated with a Peltier cooling mechanism. The cooling regimen, spanning from 20 to -17 °C, verified a 140-fold increase in the SERS signal for 1 ppm HCN, concurrently enabling the detection of HCN and Tabun concentrations as low as 0.25 and 0.5 ppm, respectively. Implementation of temperature modulation and controlled flow routines substantially reduced detection times down to 240 s for HCN, with prospects for further optimization.

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冷却SERS基板上化学威胁的气相和气相检测。

在当前动荡的全球环境中，检测空气传播的化学威胁是一项新挑战。广泛的研究表明，表面增强拉曼光谱（SERS）在现场识别液体介质中存在的危险化学品方面具有巨大的前景，无论是直接来自流体源还是通过拭子采样等方法。尽管如此，探索SERS在检测气体或气相化学威胁方面的适用性仍然受到严重限制。在这项研究中，我们展示了通过SERS成功实现了对氰化氢（HCN）和塔本（GA）化学战剂的百万分之一（ppm）检测阈值，这是由集成了珀尔捷冷却机制的定制气体取样池实现的。冷却方案从20°C到-17°C，验证了1 ppm HCN时SERS信号增加140倍，同时能够分别检测到低至0.25和0.5 ppm的HCN和Tabun浓度。温度调节和控制流量程序的实施大大减少了HCN的检测时间，低至240秒，具有进一步优化的前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Talanta 化学-分析化学

CiteScore

12.30

自引率

4.90%

发文量

861

审稿时长

29 days

期刊介绍： Talanta provides a forum for the publication of original research papers, short communications, and critical reviews in all branches of pure and applied analytical chemistry. Papers are evaluated based on established guidelines, including the fundamental nature of the study, scientific novelty, substantial improvement or advantage over existing technology or methods, and demonstrated analytical applicability. Original research papers on fundamental studies, and on novel sensor and instrumentation developments, are encouraged. Novel or improved applications in areas such as clinical and biological chemistry, environmental analysis, geochemistry, materials science and engineering, and analytical platforms for omics development are welcome. Analytical performance of methods should be determined, including interference and matrix effects, and methods should be validated by comparison with a standard method, or analysis of a certified reference material. Simple spiking recoveries may not be sufficient. The developed method should especially comprise information on selectivity, sensitivity, detection limits, accuracy, and reliability. However, applying official validation or robustness studies to a routine method or technique does not necessarily constitute novelty. Proper statistical treatment of the data should be provided. Relevant literature should be cited, including related publications by the authors, and authors should discuss how their proposed methodology compares with previously reported methods.