Diagnostic and Prognostic Significance of Exosomes and Their Components in Patients With Cancers.

IF 2.9 2区医学 Q2 ONCOLOGY

Cancer Medicine Pub Date : 2025-01-01 DOI:10.1002/cam4.70569

Zinnat Ara Moni, Zahid Hasan, Md Shaheen Alam, Nitai Roy, Farhadul Islam

{"title":"Diagnostic and Prognostic Significance of Exosomes and Their Components in Patients With Cancers.","authors":"Zinnat Ara Moni, Zahid Hasan, Md Shaheen Alam, Nitai Roy, Farhadul Islam","doi":"10.1002/cam4.70569","DOIUrl":null,"url":null,"abstract":"Background: Cancer is the second leading cause of human mortality worldwide. Extracellular vesicles (EVs) from liquid biopsy samples are used in early cancer detection, characterization, and surveillance. Exosomes are a subset of EVs produced by all cells and present in all body fluids. They play an important role in the development of cancer because they are active transporters capable of carrying the contents of any type of cell. The objective of this review was to provide a brief overview of the clinical implication of exosomes or exosomal components in cancer diagnosis and prognosis.Methods: An extensive review of the current literature of exosomes and their components in cancer diagnosis and prognosis were carried out in the current study.Results: Tumor cells release exosomes that contribute to the formation of the pre-metastatic microenvironment, angiogenesis, invasion, and treatment resistance. On the contrary, tumor cells release more exosomes than normal cells, and these tumor-specific exosomes can carry the genomic and proteomic signature contents of the tumor cells, which can act as tools for the diagnosis and prognosis of patients with cancers.Conclusion: This information may help clinicians to improve the management of cancer patients in clinical settings in the future.","PeriodicalId":139,"journal":{"name":"Cancer Medicine","volume":"14 1","pages":"e70569"},"PeriodicalIF":2.9000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/cam4.70569","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Cancer is the second leading cause of human mortality worldwide. Extracellular vesicles (EVs) from liquid biopsy samples are used in early cancer detection, characterization, and surveillance. Exosomes are a subset of EVs produced by all cells and present in all body fluids. They play an important role in the development of cancer because they are active transporters capable of carrying the contents of any type of cell. The objective of this review was to provide a brief overview of the clinical implication of exosomes or exosomal components in cancer diagnosis and prognosis.

Methods: An extensive review of the current literature of exosomes and their components in cancer diagnosis and prognosis were carried out in the current study.

Results: Tumor cells release exosomes that contribute to the formation of the pre-metastatic microenvironment, angiogenesis, invasion, and treatment resistance. On the contrary, tumor cells release more exosomes than normal cells, and these tumor-specific exosomes can carry the genomic and proteomic signature contents of the tumor cells, which can act as tools for the diagnosis and prognosis of patients with cancers.

Conclusion: This information may help clinicians to improve the management of cancer patients in clinical settings in the future.

查看原文本刊更多论文

外泌体及其成分在癌症患者中的诊断和预后意义。

背景：癌症是世界范围内人类死亡的第二大原因。来自液体活检样本的细胞外囊泡（EVs）用于早期癌症检测、表征和监测。外泌体是由所有细胞产生并存在于所有体液中的ev的一个子集。它们在癌症的发展中起着重要作用，因为它们是活跃的转运体，能够携带任何类型细胞的内容物。本综述的目的是简要概述外泌体或外泌体成分在癌症诊断和预后中的临床意义。方法：对目前有关外泌体及其成分在癌症诊断和预后中的研究进行了广泛的综述。结果：肿瘤细胞释放外泌体，促进转移前微环境的形成、血管生成、侵袭和治疗抵抗。相反，肿瘤细胞比正常细胞释放更多的外泌体，这些肿瘤特异性外泌体可以携带肿瘤细胞的基因组和蛋白质组特征内容，可以作为癌症患者诊断和预后的工具。结论：这些信息可能有助于临床医生在未来的临床环境中改善对癌症患者的管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Cancer Medicine ONCOLOGY-

CiteScore

5.50

自引率

2.50%

发文量

907

审稿时长

19 weeks

期刊介绍： Cancer Medicine is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research from global biomedical researchers across the cancer sciences. The journal will consider submissions from all oncologic specialties, including, but not limited to, the following areas: Clinical Cancer Research Translational research ∙ clinical trials ∙ chemotherapy ∙ radiation therapy ∙ surgical therapy ∙ clinical observations ∙ clinical guidelines ∙ genetic consultation ∙ ethical considerations Cancer Biology: Molecular biology ∙ cellular biology ∙ molecular genetics ∙ genomics ∙ immunology ∙ epigenetics ∙ metabolic studies ∙ proteomics ∙ cytopathology ∙ carcinogenesis ∙ drug discovery and delivery. Cancer Prevention: Behavioral science ∙ psychosocial studies ∙ screening ∙ nutrition ∙ epidemiology and prevention ∙ community outreach. Bioinformatics: Gene expressions profiles ∙ gene regulation networks ∙ genome bioinformatics ∙ pathwayanalysis ∙ prognostic biomarkers. Cancer Medicine publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper.