Global and Regional Burden of Type 2 Diabetes Mellitus Attributable to Low Physical Activity From 1990 to 2021.

IF 3 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes Pub Date : 2025-01-01 DOI:10.1111/1753-0407.70043

Lihang Yang, Diya Xie, Fengmin Liu, Jiaying Lin, Xin Lin, Yuquan Chen, Kun Zhang

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引用次数: 0

Abstract

Aim: Type 2 diabetes mellitus (T2DM) contributes to the heavy burden, but there lacks latest and comprehensive global research on the burden of T2DM attributable to low physical activity (LPA). This study aimed to quantify the global and regional burden of T2DM attributable to LPA from 1990 to 2021.

Methods: We utilized data including disability-adjusted life years (DALYs), mortality, age-standardized disability-adjusted life years (ASDR), and age-standardized mortality rates (ASMR) from the Global Burden of Disease (GBD) 2021. We assessed the burden across different ages, genders, and sociodemographic index (SDI). Joinpoint regression analysis was applied to estimated average annual percent change (AAPC).

Results: Between 1990 and 2021, DALYs and mortality of T2DM attributable to LPA increased rapidly. There was an increase in the ASDR and ASMR, with AAPC of 1.09 (95% CI: 1.03-1.16) and 0.32 (95% CI: 0.2-0.43), which was increased faster in males. Low-middle SDI countries have the highest ASDR and highest ASMR. The global PAF for ASDR and ASMR in 2021 is 7.38% and 9.45%. A U-shaped drift pattern was observed in most SDI quintiles in APC model. Population growth is a major contributor to the burden of T2DM, especially in countries with low SDI. Epidemiological changes also play an important role in DALYs and mortality. A negative correlation existed between SDI and both ASMR and ASDR.

Conclusion: Between 1990 and 2021, there was a marked rise in the global burden of T2DM associated with LPA. The findings lay the groundwork for informed decision-making a public health and healthcare delivery.

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1990年至2021年低身体活动导致的全球和区域2型糖尿病负担

目的：2型糖尿病（T2DM）是加重负担的原因之一，但目前全球缺乏关于低体力活动（LPA）导致的T2DM负担的最新、全面的研究。本研究旨在量化1990年至2021年由LPA引起的全球和区域T2DM负担。方法：我们使用来自2021年全球疾病负担（GBD）的数据，包括残疾调整生命年（DALYs）、死亡率、年龄标准化残疾调整生命年（ASDR）和年龄标准化死亡率（ASMR）。我们评估了不同年龄、性别和社会人口指数（SDI）的负担。采用联合点回归分析估计平均年变化百分数（AAPC）。结果：1990 - 2021年间，LPA导致的T2DM DALYs和死亡率迅速上升。ASDR和ASMR增加，AAPC分别为1.09 （95% CI: 1.03-1.16）和0.32 (95% CI: 0.2-0.43)，其中男性增加更快。中低SDI国家的ASDR和ASMR最高。2021年ASDR和ASMR的全球PAF分别为7.38%和9.45%。在APC模型中，大部分SDI五分位数呈u型漂移。人口增长是2型糖尿病负担的主要因素，特别是在低SDI国家。流行病学变化在伤残调整生命年和死亡率中也起着重要作用。SDI与ASMR、ASDR均呈负相关。结论：1990年至2021年间，与LPA相关的T2DM全球负担显著增加。这些发现为公共卫生和医疗保健服务的知情决策奠定了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Diabetes ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

2.20%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Diabetes (JDB) devotes itself to diabetes research, therapeutics, and education. It aims to involve researchers and practitioners in a dialogue between East and West via all aspects of epidemiology, etiology, pathogenesis, management, complications and prevention of diabetes, including the molecular, biochemical, and physiological aspects of diabetes. The Editorial team is international with a unique mix of Asian and Western participation. The Editors welcome submissions in form of original research articles, images, novel case reports and correspondence, and will solicit reviews, point-counterpoint, commentaries, editorials, news highlights, and educational content.