Diary of a cell in DNA ‘chyrons’

IF 12.9 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature chemical biology Pub Date : 2025-01-06 DOI:10.1038/s41589-024-01814-y

Chao Chen, Harris H. Wang

引用次数: 0

Abstract

Cellular recording in DNA memory is an emerging and promising strategy to document the biological activity of individual cells over time. A prime editing-based recording system using prime-editing guide RNAs (pegRNAs) has been developed to track cellular histories by making sequential insertions in the genome of mammalian cells.

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DNA“chyrons”中的细胞日记

DNA记忆中的细胞记录是一种新兴的、有前途的记录单个细胞随时间变化的生物活性的策略。一种基于引物编辑的记录系统利用引物编辑引导rna (pegRNAs)，通过在哺乳动物细胞基因组中进行序列插入来跟踪细胞历史。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature chemical biology 生物-生化与分子生物学

CiteScore

23.90

自引率

1.40%

发文量

238

审稿时长

12 months

期刊介绍： Nature Chemical Biology stands as an esteemed international monthly journal, offering a prominent platform for the chemical biology community to showcase top-tier original research and commentary. Operating at the crossroads of chemistry, biology, and related disciplines, chemical biology utilizes scientific ideas and approaches to comprehend and manipulate biological systems with molecular precision. The journal embraces contributions from the growing community of chemical biologists, encompassing insights from chemists applying principles and tools to biological inquiries and biologists striving to comprehend and control molecular-level biological processes. We prioritize studies unveiling significant conceptual or practical advancements in areas where chemistry and biology intersect, emphasizing basic research, especially those reporting novel chemical or biological tools and offering profound molecular-level insights into underlying biological mechanisms. Nature Chemical Biology also welcomes manuscripts describing applied molecular studies at the chemistry-biology interface due to the broad utility of chemical biology approaches in manipulating or engineering biological systems. Irrespective of scientific focus, we actively seek submissions that creatively blend chemistry and biology, particularly those providing substantial conceptual or methodological breakthroughs with the potential to open innovative research avenues. The journal maintains a robust and impartial review process, emphasizing thorough chemical and biological characterization.