Bioinspired Liquid Pockets with Externally Induced Internal Microscale Flow

IF 27.4 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Lian Xu, Feng Wu, Yigang Shen, Yi Fan, Shuli Wang, Xu Hou
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引用次数: 0

Abstract

The gastric mucosal barrier, through its gastric pits, serves as a pathway for secretions, ensuring that mucus produced by the gastric glands is transferred to the gastric lumen, providing stable protection. Here a bioinspired liquid pockets material is shown, composed of a thermo-driven hydrogel that acts as an external activation unit to release interflowing liquid responsively, and porous matrices that serve as interconnected pockets to transfer it, enabling controlled internal flow and adaptive barrier functionality. Experiments and theoretical analysis demonstrate the stability and regulatory mechanisms of these liquid pockets, based on the interconnected pockets between the external activation unit and internal fluid flow. It exhibits a new pathway for regulating microscale flow at responsive material interfaces, enabling applications from sequential drug release, self-cleaning, and antifouling to anti-swelling. These unique capabilities address long-standing challenges in microscale flow control, with potential impacts in diverse fields including microfluidics, drug delivery, medical devices, 3D printing, and beyond.

Abstract Image

Abstract Image

具有外部诱导内部微尺度流动的生物启发液体口袋
胃粘膜屏障通过其胃窝作为分泌物的通道,确保胃腺产生的粘液转移到胃腔,提供稳定的保护。这里展示了一种受生物启发的液体口袋材料,由热驱动的水凝胶组成,它作为外部激活单元,响应性地释放相互流动的液体,多孔基质作为相互连接的口袋来转移液体,实现受控的内部流动和自适应屏障功能。实验和理论分析证明了这些液穴的稳定性和调节机制,这些液穴是基于外部激活单元和内部流体流动之间的相互连接的。它展示了在响应性材料界面上调节微尺度流动的新途径,使从顺序药物释放、自清洁、防污到抗肿胀的应用成为可能。这些独特的功能解决了长期以来在微尺度流动控制方面的挑战,在微流体、药物输送、医疗设备、3D打印等多个领域都有潜在的影响。
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来源期刊
Advanced Materials
Advanced Materials 工程技术-材料科学:综合
CiteScore
43.00
自引率
4.10%
发文量
2182
审稿时长
2 months
期刊介绍: Advanced Materials, one of the world's most prestigious journals and the foundation of the Advanced portfolio, is the home of choice for best-in-class materials science for more than 30 years. Following this fast-growing and interdisciplinary field, we are considering and publishing the most important discoveries on any and all materials from materials scientists, chemists, physicists, engineers as well as health and life scientists and bringing you the latest results and trends in modern materials-related research every week.
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