Enhancing adipose tissue plasticity: progenitor cell roles in metabolic health

IF 31 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Nature Reviews Endocrinology Pub Date : 2025-01-06 DOI:10.1038/s41574-024-01071-y

Simon Lecoutre, Clémentine Rebière, Salwan Maqdasy, Mélanie Lambert, Sébastien Dussaud, Jimon Boniface Abatan, Isabelle Dugail, Emmanuel L. Gautier, Karine Clément, Geneviève Marcelin

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Abstract

Adipose tissue demonstrates considerable plasticity and heterogeneity, enabling metabolic, cellular and structural adaptations to environmental signals. This adaptability is key for maintaining metabolic homeostasis. Impaired adipose tissue plasticity can lead to abnormal adipose tissue responses to metabolic cues, which contributes to the development of cardiometabolic diseases. In chronic obesity, white adipose tissue undergoes pathological remodelling marked by adipocyte hypertrophy, chronic inflammation and fibrosis, which are linked to local and systemic insulin resistance. Research data suggest that the capacity for healthy or unhealthy white adipose tissue remodelling might depend on the intrinsic diversity of adipose progenitor cells (APCs), which sense and respond to metabolic cues. This Review highlights studies on APCs as key determinants of adipose tissue plasticity, discussing differences between subcutaneous and visceral adipose tissue depots during development, growth and obesity. Modulating APC functions could improve strategies for treating adipose tissue dysfunction and metabolic diseases in obesity.

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增强脂肪组织可塑性：祖细胞在代谢健康中的作用

脂肪组织表现出相当大的可塑性和异质性，使代谢、细胞和结构适应环境信号。这种适应性是维持代谢稳态的关键。脂肪组织可塑性受损可导致脂肪组织对代谢信号的异常反应，从而导致心脏代谢疾病的发生。在慢性肥胖中，白色脂肪组织经历病理性重塑，其特征是脂肪细胞肥大、慢性炎症和纤维化，这与局部和全身胰岛素抵抗有关。研究数据表明，健康或不健康白色脂肪组织重塑的能力可能取决于脂肪祖细胞（APCs）的内在多样性，APCs感知并响应代谢信号。本综述重点介绍了APCs作为脂肪组织可塑性关键决定因素的研究，讨论了在发育、生长和肥胖过程中皮下和内脏脂肪组织储存的差异。调节APC功能可以改善肥胖患者脂肪组织功能障碍和代谢疾病的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Endocrinology 医学-内分泌学与代谢

CiteScore

42.00

自引率

0.70%

发文量

158

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Endocrinology aspires to be the foremost platform for reviews and commentaries catering to the scientific communities it serves. The journal aims to publish articles characterized by authority, accessibility, and clarity, enhanced with easily understandable figures, tables, and other visual aids. The goal is to offer an unparalleled service to authors, referees, and readers, striving to maximize the usefulness and impact of each article. Nature Reviews Endocrinology publishes Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives relevant to researchers and clinicians in the fields of endocrinology and metabolism. Its broad scope ensures that the work it publishes reaches the widest possible audience.