Donor–Acceptor Functionalized Water-Soluble Metal–Organic Cages Showing an Excellent Synergistic Photothermal–Chemotherapy Effect

IF 9.6 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Letters Pub Date : 2025-01-06 DOI:10.1021/acs.nanolett.4c05264

Xing-Wang Li, Yongkang Huang, Han Fang, Han-Yu Wang, He Sun, Mei-Hui Yu, Yaping Du, Ze Chang, Xian-He Bu

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引用次数: 0

Abstract

Water-soluble metal–organic cages (WSMOCs) show high potential as antitumor agents, while the targeted functionalization of WSMOCs toward enhanced antitumor performances is a challenging task. Herein, WSMOCs were functionalized with donor–acceptor (D–A) systems for synergistic photothermal–chemotherapy. Octahedral [M₆L₄] cages based on a 2,4,6-tri(2-pyridine-4-yl)-1,3,5-triazine (TPT) acceptor and M(bpy)²⁺ (M = Pd for 1a, Pt for 1b) nodes were functionalized with tetrathiafulvalene (TTF) to form TTF@1a and TTF@1b. This D–A functionalization enhanced charge transfer, extending absorption into the near-infrared region with photothermal conversion efficiencies of 35.65% for TTF@1a and 40.65% for TTF@1b. Also, the D–A functionalization was found to enhance the stability of the compound and induce their aggregation into nanoparticles to increase their cellular compatibility. Additionally, the acidic-sensitive ion release feature of the compounds made them promising for targeted chemotherapy. In vitro and in vivo tests demonstrated the effectiveness of this synergistic approach for antitumor applications.

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来源期刊

Nano Letters 工程技术-材料科学：综合

CiteScore

16.80

自引率

2.80%

发文量

1182

审稿时长

1.4 months

期刊介绍： Nano Letters serves as a dynamic platform for promptly disseminating original results in fundamental, applied, and emerging research across all facets of nanoscience and nanotechnology. A pivotal criterion for inclusion within Nano Letters is the convergence of at least two different areas or disciplines, ensuring a rich interdisciplinary scope. The journal is dedicated to fostering exploration in diverse areas, including: - Experimental and theoretical findings on physical, chemical, and biological phenomena at the nanoscale - Synthesis, characterization, and processing of organic, inorganic, polymer, and hybrid nanomaterials through physical, chemical, and biological methodologies - Modeling and simulation of synthetic, assembly, and interaction processes - Realization of integrated nanostructures and nano-engineered devices exhibiting advanced performance - Applications of nanoscale materials in living and environmental systems Nano Letters is committed to advancing and showcasing groundbreaking research that intersects various domains, fostering innovation and collaboration in the ever-evolving field of nanoscience and nanotechnology.