The effect of eight weeks of aerobic training with vitamin C on some apoptotic markers in the hippocampus tissue of rats with Alzheimer's disease; an experimental study.

IF 1.7 4区医学 Q3 CLINICAL NEUROLOGY

Neurological Research Pub Date : 2025-01-04 DOI:10.1080/01616412.2024.2448624

Azadeh Farzi, Amin Teymoor Davani, Asiye Seyed, Omidreza Salehi, Zahra Mosallanezhad

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引用次数: 0

Abstract

Objectives: The aim of this study was to investigate the effect of eight weeks of aerobic training (AT) and vitamin C supplementation (VC) on apoptotic markers in hippocampus tissue of AD rats treated with trimethyltin (TMT).

Materials and methods: In this experimental study, 32 Sprague- Dawley rats (mean age: 14-18 months and mean weight 270-320 g) were treated with (10 mg/kg) TMT and divided into 4 groups including: 1) ADcontrol, 2) VC, 3) AT and 4) AT+VC groups. In order to investigate the effects of AD induction on research variables, 8 healthy rats selected as healthy control group (HC). Groups 3 and 4 trained for eight weeks, three sessions per week and each session lasted 15-48 minutes with an intensity of 10-24 m/min. Groups 2 and 4 received 4 mg/kg VC orally. One-way ANOVA with Tukey's post- hoc tests were used for statistical analysis of data (p ≤ 0.05).

Results: The gene expression levels of Caspase 3, FasL, Cyt-C and AP-1 in the AT, VC and AT+VC groups were significantly lower than TMT group (p ≤ 0.05); Caspase 3, FasL and Cyt-C levels were significantly lower in the AT+VC group compare to VC and ET groups (p ≤ 0.05). CytC levels in AT group were significantly lower than VC group (p = 0.002). Also, AP-1 levels in AT+VC group were significantly lower than AT group (p = 0.01).

Conclusions: It seems that AT and VC, both alone and interactively, can probably induce their anti-apoptotic effects in the hippocampus tissue of rats with AD via a common signaling pathway.

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8周维生素C有氧训练对阿尔茨海默病大鼠海马组织部分凋亡标志物的影响一项实验性研究。

目的：本研究旨在探讨有氧训练（AT）和补充维生素C （VC）对三甲基锡（TMT）治疗AD大鼠海马组织凋亡标志物的影响。材料与方法：选用平均年龄14 ~ 18月龄、平均体重270 ~ 320 g的32只Sprague- Dawley大鼠，经（10 mg/kg） TMT治疗，分为4组：1)ADcontrol组、2)VC组、3)AT组和4)AT+VC组。为了研究AD诱导对研究变量的影响，选取8只健康大鼠作为健康对照组（HC）。第3组和第4组训练8周，每周3次，每次15-48分钟，强度为10-24 m/min。2组和4组口服VC 4 mg/kg。资料采用单因素方差分析加Tukey事后检验（p≤0.05）。结果：AT、VC和AT+VC组Caspase 3、FasL、Cyt-C、AP-1基因表达水平均显著低于TMT组（p≤0.05）；AT+VC组Caspase 3、FasL、Cyt-C水平显著低于VC组和ET组（p≤0.05）。AT组CytC水平显著低于VC组（p = 0.002）。AT+VC组AP-1水平显著低于AT组（p = 0.01）。结论：AT和VC单独或相互作用可能通过共同的信号通路诱导AD大鼠海马组织的抗凋亡作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurological Research 医学-临床神经学

CiteScore

3.60

自引率

0.00%

发文量

116

审稿时长

5.3 months

期刊介绍： Neurological Research is an international, peer-reviewed journal for reporting both basic and clinical research in the fields of neurosurgery, neurology, neuroengineering and neurosciences. It provides a medium for those who recognize the wider implications of their work and who wish to be informed of the relevant experience of others in related and more distant fields. The scope of the journal includes: •Stem cell applications •Molecular neuroscience •Neuropharmacology •Neuroradiology •Neurochemistry •Biomathematical models •Endovascular neurosurgery •Innovation in neurosurgery.