Ambulatory blood pressure profiles of children with asthma compared to healthy controls.

IF 2.6 3区医学 Q1 PEDIATRICS

Pediatric Nephrology Pub Date : 2025-05-01 Epub Date: 2025-01-04 DOI:10.1007/s00467-024-06615-y

Adem Yasin Köksoy, Yurda Şimşek, Serdar Epçaçan, Umut Selda Bayrakci

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Abstract

Background: Studies suggest that asthma and hypertension may be comorbid conditions. Most of these studies are epidemiological research. However, data on the relationship between asthma and hypertension in childhood are limited. We aimed to evaluate ambulatory blood pressure profiles of children with asthma.

Methods: Children aged 5-18 with asthma were evaluated using ABPM. The control group included healthy age- and sex-matched volunteers. A total of 26 patients with asthma and 20 controls were enrolled.

Results: Children with asthma had higher mean 24-h systolic blood pressure (SBP) SDS (standard deviation score) compared to controls (mean difference: 0.84, 0.19 ± 1.14 vs. - 0.65 ± 1.09, p = 0.015). Daytime SBP SDS was higher in those with asthma (mean difference: 0.83, 0.009 ± 1.22 vs. - 0.82 ± 1.09, p = 0.021), as was nighttime SBP SDS (mean difference: 0.74, 0.64 ± 1.09 vs. - 0.10 ± 0.79, p = 0.013). Median nighttime SBP load was higher in those with asthma (p = 0.006). Nondipping status was found in 23.1% of patients with asthma (none in controls, p = 0.021). One patient (3.8%) had ambulatory hypertension and six (23.1%) had masked hypertension (none in controls, p = 0.042). Extended use of inhaled corticosteroids was associated with a 2% increase in the odds of developing hypertension (OR 1.02, p = 0.025).

Conclusions: Children with asthma may be at greater risk for developing hypertension compared to healthy counterparts. Ambulatory blood pressure tends to be higher in children with asthma than healthy peers. Inhaled steroids potentially contribute to elevated BP levels in children with asthma.

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哮喘儿童与健康对照的动态血压谱

背景：研究表明哮喘和高血压可能是合并症。这些研究大多是流行病学研究。然而，关于儿童哮喘和高血压之间关系的数据有限。我们的目的是评估哮喘儿童的动态血压特征。方法：采用ABPM法对5 ~ 18岁哮喘患儿进行评价。对照组包括年龄和性别匹配的健康志愿者。共有26名哮喘患者和20名对照组被纳入研究。结果：哮喘患儿平均24小时收缩压（SBP） SDS（标准差评分）高于对照组（平均差值：0.84,0.19±1.14比- 0.65±1.09,p = 0.015）。哮喘患者白天收缩压SDS较高（平均差值：0.83,0.009±1.22 vs - 0.82±1.09,p = 0.021），夜间收缩压SDS较高（平均差值：0.74,0.64±1.09 vs - 0.10±0.79,p = 0.013）。哮喘患者夜间收缩压负荷中位数较高（p = 0.006）。23.1%的哮喘患者无浸染状态（对照组无，p = 0.021）。1例患者（3.8%）有动态高血压，6例患者（23.1%）有隐匿性高血压（对照组无一例，p = 0.042）。长期使用吸入性皮质类固醇与发生高血压的几率增加2%相关（OR 1.02, p = 0.025）。结论：与健康儿童相比，哮喘儿童患高血压的风险更高。哮喘儿童的动态血压往往高于健康的同龄人。吸入类固醇可能导致哮喘儿童血压升高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Nephrology 医学-泌尿学与肾脏学

CiteScore

4.70

自引率

20.00%

发文量

465

审稿时长

1 months

期刊介绍： International Pediatric Nephrology Association Pediatric Nephrology publishes original clinical research related to acute and chronic diseases that affect renal function, blood pressure, and fluid and electrolyte disorders in children. Studies may involve medical, surgical, nutritional, physiologic, biochemical, genetic, pathologic or immunologic aspects of disease, imaging techniques or consequences of acute or chronic kidney disease. There are 12 issues per year that contain Editorial Commentaries, Reviews, Educational Reviews, Original Articles, Brief Reports, Rapid Communications, Clinical Quizzes, and Letters to the Editors.