Impact of high maternal body mass index on fetal cerebral cortical and cerebellar volumes.

IF 1.7 4区 医学 Q3 OBSTETRICS & GYNECOLOGY
Emiko Takeoka, April A Carlson, Neel Madan, Afshin Azimirad, Taysir Mahmoud, Rie Kitano, Shizuko Akiyama, Hyuk Jin Yun, Richard Tucker, Kiho Im, Perrie O'Tierney-Ginn, Tomo Tarui
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引用次数: 0

Abstract

Objectives: Maternal obesity increases a child's risk of neurodevelopmental impairment. However, little is known about the impact of maternal obesity on fetal brain development.

Methods: We prospectively recruited 20 healthy pregnant women across the range of pre-pregnancy or first-trimester body mass index (BMI) and performed fetal brain magnetic resonance imaging (MRI) of their healthy singleton fetuses. We examined correlations between early pregnancy maternal BMI and regional brain volume of living fetuses using volumetric MRI analysis.

Results: Of 20 fetuses, there were 8 males and 12 females (median gestational age at MRI acquisition was 24.3 weeks, range: 19.7-33.3 weeks, median maternal age was 33.3 years, range: 22.0-37.4 years). There were no significant differences in clinical demographics between overweight (OW, 25≤BMI<30)/obese (OB, BMI≥30 kg/m2) (n=12) and normal BMI (18.5≤BMI<25) (n=8) groups. Fetuses in the OW/OB group had significantly larger left cortical plate (p=0.0003), right cortical plate (p=0.0002), and whole cerebellum (p=0.049) compared to the normal BMI group. In the OW/OB BMI group, cortical plate volume was larger relative to other brain regions after 28 weeks.

Conclusions: This pilot study supports the concept that maternal obesity impacts fetal brain volume, detectable via MRI in living fetuses using quantitative analysis.

高母亲体重指数对胎儿大脑皮质和小脑体积的影响。
目的:母亲肥胖增加儿童神经发育障碍的风险。然而,我们对母亲肥胖对胎儿大脑发育的影响知之甚少。方法:我们前瞻性地招募了20名健康孕妇,在孕前或孕早期体重指数(BMI)的范围内,对她们健康的单胎胎儿进行了胎儿脑磁共振成像(MRI)。我们使用体积核磁共振分析检查了妊娠早期母体BMI与活胎局部脑容量之间的相关性。结果:20例胎儿中,男8例,女12例(MRI采集时胎龄中位数为24.3周,范围为19.7 ~ 33.3周,产妇年龄中位数为33.3岁,范围为22.0 ~ 37.4岁)。超重(OW, 25≤BMI2) (n=12)和正常BMI(18.5≤BMI2)在临床人口统计学上无显著差异。结论:本初步研究支持孕妇肥胖影响胎儿脑容量的概念,通过MRI对活胎进行定量分析。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Perinatal Medicine
Journal of Perinatal Medicine 医学-妇产科学
CiteScore
4.40
自引率
8.30%
发文量
183
审稿时长
4-8 weeks
期刊介绍: The Journal of Perinatal Medicine (JPM) is a truly international forum covering the entire field of perinatal medicine. It is an essential news source for all those obstetricians, neonatologists, perinatologists and allied health professionals who wish to keep abreast of progress in perinatal and related research. Ahead-of-print publishing ensures fastest possible knowledge transfer. The Journal provides statements on themes of topical interest as well as information and different views on controversial topics. It also informs about the academic, organisational and political aims and objectives of the World Association of Perinatal Medicine.
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