Understanding structural-functional connectivity coupling in patients with major depressive disorder: A white matter perspective

IF 4.9 2区 医学 Q1 CLINICAL NEUROLOGY
Tongpeng Chu , Xiaopeng Si , Xicheng Song , Kaili Che , Fanghui Dong , Yuting Guo , Danni Chen , Wei Yao , Feng Zhao , Haizhu Xie , Yinghong Shi , Heng Ma , Dong Ming , Ning Mao
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引用次数: 0

Abstract

Purpose

To elucidate the structural-functional connectivity (SC-FC) coupling in white matter (WM) tracts in patients with major depressive disorder (MDD).

Methods

A total of 178 individuals diagnosed with MDD and 173 healthy controls (HCs) were recruited for this study. The Euclidean distance was calculated to assess SC-FC coupling. The primary analyses focused on investigating alterations in SC-FC coupling in WM tracts of individuals with MDD. Additionally, we explored the association between coupling and clinical symptoms. Secondary analyses examined differences among three subgroups of MDD: those with suicidal ideation (SI), those with a history of suicidal attempts (SA), and those non-suicidal (NS).

Results

The study revealed increased SC-FC coupling mainly in the middle cerebellar peduncle and bilateral corticospinal tract (PFDR < 0.05) in patients with MDD compared with HCs. Additionally, right cerebral peduncle coupling strength exhibited a significant positive correlation with Hamilton Anxiety Scale scores (r = 0.269, PFDR = 0.041), while right cingulum (hippocampus) coupling strength showed a significant negative correlation with Nurses' Global Assessment of Suicide Risk scores (r = −0.159, PFDR = 0.036). An increase in left anterior limb of internal capsule (PBonferroni < 0.01) and left corticospinal tract (PBonferroni < 0.05) coupling has been observed in MDD with SI. Additionally, a decrease in right posterior limb of internal capsule coupling has been found in MDD with SA (PBonferroni < 0.05).

Conclusions

This study emphasizes the variations in SC-FC coupling in WM tracts in individuals with MDD and its subgroups, highlighting the crucial role of WM networks in the pathophysiology of MDD.
理解重度抑郁症患者的结构-功能连接耦合:白质视角。
目的:探讨重度抑郁症(MDD)患者脑白质束的结构-功能连接(SC-FC)耦合。方法:本研究共招募了178名诊断为重度抑郁症的个体和173名健康对照(hc)。计算欧几里得距离来评估SC-FC耦合。主要的分析集中在研究重度抑郁症患者WM束中SC-FC偶联的改变。此外,我们探讨了耦合与临床症状之间的关系。二级分析检查了MDD的三个亚组之间的差异:有自杀意念(SI)、有自杀企图史(SA)和无自杀倾向(NS)。结果:研究发现SC-FC耦合增加主要发生在小脑中脚和双侧皮质脊髓束(PFDR FDR = 0.041),而右侧扣带(海马)耦合强度与护士自杀风险综合评估评分呈显著负相关(r = -0.159,PFDR = 0.036)。左前肢内囊增加(PBonferroni Bonferroni Bonferroni )结论:本研究强调了重度抑郁症患者及其亚组WM束中SC-FC偶联的变化,强调了WM网络在重度抑郁症病理生理中的重要作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of affective disorders
Journal of affective disorders 医学-精神病学
CiteScore
10.90
自引率
6.10%
发文量
1319
审稿时长
9.3 weeks
期刊介绍: The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.
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