Tongpeng Chu , Xiaopeng Si , Xicheng Song , Kaili Che , Fanghui Dong , Yuting Guo , Danni Chen , Wei Yao , Feng Zhao , Haizhu Xie , Yinghong Shi , Heng Ma , Dong Ming , Ning Mao
{"title":"Understanding structural-functional connectivity coupling in patients with major depressive disorder: A white matter perspective","authors":"Tongpeng Chu , Xiaopeng Si , Xicheng Song , Kaili Che , Fanghui Dong , Yuting Guo , Danni Chen , Wei Yao , Feng Zhao , Haizhu Xie , Yinghong Shi , Heng Ma , Dong Ming , Ning Mao","doi":"10.1016/j.jad.2024.12.082","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><div>To elucidate the structural-functional connectivity (SC-FC) coupling in white matter (WM) tracts in patients with major depressive disorder (MDD).</div></div><div><h3>Methods</h3><div>A total of 178 individuals diagnosed with MDD and 173 healthy controls (HCs) were recruited for this study. The Euclidean distance was calculated to assess SC-FC coupling. The primary analyses focused on investigating alterations in SC-FC coupling in WM tracts of individuals with MDD. Additionally, we explored the association between coupling and clinical symptoms. Secondary analyses examined differences among three subgroups of MDD: those with suicidal ideation (SI), those with a history of suicidal attempts (SA), and those non-suicidal (NS).</div></div><div><h3>Results</h3><div>The study revealed increased SC-FC coupling mainly in the middle cerebellar peduncle and bilateral corticospinal tract (<em>P</em><sub>FDR</sub> < 0.05) in patients with MDD compared with HCs. Additionally, right cerebral peduncle coupling strength exhibited a significant positive correlation with Hamilton Anxiety Scale scores (<em>r</em> = 0.269, <em>P</em><sub>FDR</sub> = 0.041), while right cingulum (hippocampus) coupling strength showed a significant negative correlation with Nurses' Global Assessment of Suicide Risk scores (<em>r</em> = −0.159, <em>P</em><sub>FDR</sub> = 0.036). An increase in left anterior limb of internal capsule (<em>P</em><sub>Bonferroni</sub> < 0.01) and left corticospinal tract (<em>P</em><sub>Bonferroni</sub> < 0.05) coupling has been observed in MDD with SI. Additionally, a decrease in right posterior limb of internal capsule coupling has been found in MDD with SA (<em>P</em><sub>Bonferroni</sub> < 0.05).</div></div><div><h3>Conclusions</h3><div>This study emphasizes the variations in SC-FC coupling in WM tracts in individuals with MDD and its subgroups, highlighting the crucial role of WM networks in the pathophysiology of MDD.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"373 ","pages":"Pages 219-226"},"PeriodicalIF":4.9000,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of affective disorders","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0165032724020706","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose
To elucidate the structural-functional connectivity (SC-FC) coupling in white matter (WM) tracts in patients with major depressive disorder (MDD).
Methods
A total of 178 individuals diagnosed with MDD and 173 healthy controls (HCs) were recruited for this study. The Euclidean distance was calculated to assess SC-FC coupling. The primary analyses focused on investigating alterations in SC-FC coupling in WM tracts of individuals with MDD. Additionally, we explored the association between coupling and clinical symptoms. Secondary analyses examined differences among three subgroups of MDD: those with suicidal ideation (SI), those with a history of suicidal attempts (SA), and those non-suicidal (NS).
Results
The study revealed increased SC-FC coupling mainly in the middle cerebellar peduncle and bilateral corticospinal tract (PFDR < 0.05) in patients with MDD compared with HCs. Additionally, right cerebral peduncle coupling strength exhibited a significant positive correlation with Hamilton Anxiety Scale scores (r = 0.269, PFDR = 0.041), while right cingulum (hippocampus) coupling strength showed a significant negative correlation with Nurses' Global Assessment of Suicide Risk scores (r = −0.159, PFDR = 0.036). An increase in left anterior limb of internal capsule (PBonferroni < 0.01) and left corticospinal tract (PBonferroni < 0.05) coupling has been observed in MDD with SI. Additionally, a decrease in right posterior limb of internal capsule coupling has been found in MDD with SA (PBonferroni < 0.05).
Conclusions
This study emphasizes the variations in SC-FC coupling in WM tracts in individuals with MDD and its subgroups, highlighting the crucial role of WM networks in the pathophysiology of MDD.
期刊介绍:
The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.