Research progress of non-coding RNA regulating the role of PANoptosis in diabetes mellitus and its complications.

IF 6.1 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Apoptosis Pub Date : 2025-01-04 DOI:10.1007/s10495-024-02066-w

Guangyu Han, Kaibo Hu, Tianfeng Luo, Wenting Wang, Deju Zhang, Liu Ouyang, Xiao Liu, Jianping Liu, Yuting Wu, Jianqi Liang, Jitao Ling, Yixuan Chen, Rui Xuan, Jing Zhang, Peng Yu

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引用次数: 0

Abstract

Diabetes is a chronic metabolic disease that is endemic worldwide and is characterized by persistent hyperglycemia accompanied by multiple severe complications, including cardiovascular disease, kidney dysfunction, neuropathy, and retinopathy. The pathogenesis of diabetes mellitus and its complications is multifactorial, involving various molecular and cellular pathways. In recent years, research has indicated that mechanisms of cell death play a significant role in the advancement of diabetes and its complications. PANoptosis is a complex phenomenon caused by three cell death pathways: programmed apoptosis, necroptosis and pyroptosis. The contribution of PANoptosis to diabetes and its complications remains incompletely understood. Non-coding RNA, an important molecule in gene expression regulation, has shown significant regulatory functions in a variety of diseases. This paper reviews the underlying mechanisms of diverse types of non-coding RNAs (including lncRNA, miRNA and circRNA) in regulating PANoptosis and their specific contributions in diabetes, aiming to explore how non-coding RNAs influence PANoptosis and their effects in diabetes.

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非编码RNA调控PANoptosis在糖尿病及其并发症中的作用研究进展。

糖尿病是一种慢性代谢性疾病，在世界范围内流行，其特征是持续高血糖并伴有多种严重并发症，包括心血管疾病、肾功能障碍、神经病变和视网膜病变。糖尿病及其并发症的发病是多因素的，涉及多种分子和细胞途径。近年来的研究表明，细胞死亡机制在糖尿病及其并发症的进展中起着重要作用。PANoptosis是由程序性凋亡、坏死坏死和焦亡三种细胞死亡途径引起的复杂现象。PANoptosis对糖尿病及其并发症的影响尚不完全清楚。非编码RNA是调控基因表达的重要分子，在多种疾病中显示出重要的调控作用。本文综述了不同类型的非编码rna（包括lncRNA、miRNA和circRNA）调控PANoptosis的潜在机制及其在糖尿病中的具体作用，旨在探讨非编码rna如何影响PANoptosis及其在糖尿病中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Apoptosis 生物-生化与分子生物学

CiteScore

9.10

自引率

4.20%

发文量

审稿时长

1 months

期刊介绍： Apoptosis, a monthly international peer-reviewed journal, focuses on the rapid publication of innovative investigations into programmed cell death. The journal aims to stimulate research on the mechanisms and role of apoptosis in various human diseases, such as cancer, autoimmune disease, viral infection, AIDS, cardiovascular disease, neurodegenerative disorders, osteoporosis, and aging. The Editor-In-Chief acknowledges the importance of advancing clinical therapies for apoptosis-related diseases. Apoptosis considers Original Articles, Reviews, Short Communications, Letters to the Editor, and Book Reviews for publication.