Triglyceride-Glucose Index as a Predictor of Cardiovascular Events in Psoriatic Patients on Systemic Therapy: A 150-Patient Observational Study.

Abstract

Psoriasis is consistently associated with an elevated cardiovascular risk. However, biochemical parameters are needed to predict cardiovascular events in these patients. Therefore, we conducted a retrospective cohort study with psoriatic patients undergoing systemic treatment to analyze the value of the triglyceride-glucose (TyG) index in predicting the development of major adverse cardiovascular events (MACE). A total of 150 patients were selected, 12 of whom developed MACE (11 myocardial infarctions and one stroke) after a median follow-up of 17 months. The highest quartile of the TyG index was associated with a greater risk of developing MACE (HR, 9.3; 95%CI, 1.1-78.9). The predictive capabilities of the TyG index for predicting these events showed an area under the curve of 0.75 (0.60-0.90), P=0.001. These results demostrate that the TyG index could be useful in the early identification of psoriatic patients at high risk of developing MACE.