{"title":"Investigation of structure, optical, and photothermal properties in MoS2/Fe3O4/CuS nanocomposite for doxorubicin delivery","authors":"Maryam Mahmoodabadi, Mohammad Taghi Goodarzi, Nasrin Salehi, Alireza Jalali, Ehsan Zahedi","doi":"10.1007/s00339-024-08202-2","DOIUrl":null,"url":null,"abstract":"<div><p>The objective of the present study is to develop a novel nanocomposite platform for drug delivery, and photothermal therapy. Molybdenum disulfide (MoS<sub>2</sub>) nanosheet, as one of the most stable transitional metal dichalcogenides, indicates unique structure, thermal, and optical properties. In this work, MFC nanocomposite was synthesized from MoS<sub>2</sub> nanosheets, iron oxide (Fe<sub>3</sub>O<sub>4</sub>) nanoparticles, and copper monosulfide (CuS) nanoparticles. Then structural, morphology, and optical properties of the nanocomposite were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDS), fourier transform infrared (FTIR), and ultraviolet-visible (UV-Vis) spectroscopies. After that, a photothermal experiment was done for the MFC nanocomposite with different concentrations (50, 100, 150, 200, and 400 ppm). Photothermal experiments indicated that nanocomposite with the concentration of 400 ppm have produced the highest photothermal heat (58.3<span>\\(\\:℃\\:\\)</span>) after 10 min near infrared (NIR) laser irradiation. Then, a doxorubicin (DOX) drug was loaded into the nanocomposite. It was further studied for in-vitro DOX release with, and without laser irradiation. Results indicated that in the presence of NIR laser irradiation (1 W/cm<sup>2</sup>), the optimized DOX/MFC nanocomposite show a controlled drug release of 63.5% in pH = 5.8 after 4 h. Finally, the cytotoxicity of MFC nanocomposite on Hela cells was assessed using an MTT assay. The result of the MTT assay shows that 69.9% of Hela cells were killed by the nanocomposite at the concentration of 400 µg/mL, and under an 808 nm laser irradiation. Finally, a DOX drug was loaded in the nanocomposite with different concentrations. Results illustrated that in the presence of NIR- laser radiation (1 W/cm<sup>2</sup>) cells viability were decreased when DOX concentration was increased in the nanocomposite. Therefore, the MFC nanocomposite at the concentration of 400 ppm was suggested as a good candidate in photothermal therapy, and drug delivery.</p></div>","PeriodicalId":473,"journal":{"name":"Applied Physics A","volume":"131 1","pages":""},"PeriodicalIF":2.8000,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Applied Physics A","FirstCategoryId":"4","ListUrlMain":"https://link.springer.com/article/10.1007/s00339-024-08202-2","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
The objective of the present study is to develop a novel nanocomposite platform for drug delivery, and photothermal therapy. Molybdenum disulfide (MoS2) nanosheet, as one of the most stable transitional metal dichalcogenides, indicates unique structure, thermal, and optical properties. In this work, MFC nanocomposite was synthesized from MoS2 nanosheets, iron oxide (Fe3O4) nanoparticles, and copper monosulfide (CuS) nanoparticles. Then structural, morphology, and optical properties of the nanocomposite were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDS), fourier transform infrared (FTIR), and ultraviolet-visible (UV-Vis) spectroscopies. After that, a photothermal experiment was done for the MFC nanocomposite with different concentrations (50, 100, 150, 200, and 400 ppm). Photothermal experiments indicated that nanocomposite with the concentration of 400 ppm have produced the highest photothermal heat (58.3\(\:℃\:\)) after 10 min near infrared (NIR) laser irradiation. Then, a doxorubicin (DOX) drug was loaded into the nanocomposite. It was further studied for in-vitro DOX release with, and without laser irradiation. Results indicated that in the presence of NIR laser irradiation (1 W/cm2), the optimized DOX/MFC nanocomposite show a controlled drug release of 63.5% in pH = 5.8 after 4 h. Finally, the cytotoxicity of MFC nanocomposite on Hela cells was assessed using an MTT assay. The result of the MTT assay shows that 69.9% of Hela cells were killed by the nanocomposite at the concentration of 400 µg/mL, and under an 808 nm laser irradiation. Finally, a DOX drug was loaded in the nanocomposite with different concentrations. Results illustrated that in the presence of NIR- laser radiation (1 W/cm2) cells viability were decreased when DOX concentration was increased in the nanocomposite. Therefore, the MFC nanocomposite at the concentration of 400 ppm was suggested as a good candidate in photothermal therapy, and drug delivery.
本研究的目的是开发一种新型的纳米复合材料平台，用于药物传递和光热治疗。二硫化钼（MoS2）纳米片作为最稳定的过渡金属二硫族化合物之一，具有独特的结构、热学和光学性质。在这项工作中，MFC纳米复合材料是由二硫化钼纳米片、氧化铁（Fe3O4）纳米颗粒和单硫化铜（cu）纳米颗粒合成的。然后利用x射线衍射（XRD）、透射电子显微镜（TEM）、能量色散x射线能谱（EDS）、傅里叶变换红外光谱（FTIR）和紫外可见（UV-Vis）光谱对纳米复合材料的结构、形貌和光学性能进行了表征。然后，对不同浓度（50、100、150、200和400 ppm）的MFC纳米复合材料进行光热实验。光热实验表明，400 ppm浓度的纳米复合材料在近红外激光照射10 min后产生的光热最高（58.3 \(\:℃\:\)）。然后，将阿霉素（DOX）药物加载到纳米复合材料中。进一步研究了在激光照射和不照射下DOX的体外释放。结果表明，在1 W/cm2的近红外激光照射下，优化后的DOX/MFC纳米复合材料的释药率为63.5% in pH = 5.8 after 4 h. Finally, the cytotoxicity of MFC nanocomposite on Hela cells was assessed using an MTT assay. The result of the MTT assay shows that 69.9% of Hela cells were killed by the nanocomposite at the concentration of 400 µg/mL, and under an 808 nm laser irradiation. Finally, a DOX drug was loaded in the nanocomposite with different concentrations. Results illustrated that in the presence of NIR- laser radiation (1 W/cm2) cells viability were decreased when DOX concentration was increased in the nanocomposite. Therefore, the MFC nanocomposite at the concentration of 400 ppm was suggested as a good candidate in photothermal therapy, and drug delivery.
期刊介绍：
Applied Physics A publishes experimental and theoretical investigations in applied physics as regular articles, rapid communications, and invited papers. The distinguished 30-member Board of Editors reflects the interdisciplinary approach of the journal and ensures the highest quality of peer review.
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