M. V. Martinov, F. I. Ataullakhanov, V. M. Vitvitsky
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引用次数: 0
Abstract
A mathematical model of glycolysis in mammalian skeletal muscles is presented for the first time, in which stationary concentrations of intermediate metabolites of glycolysis are in good agreement with experimental data obtained in resting muscles. The correspondence between model and experimental values of metabolite concentrations was achieved due to the increased inhibitory effect of ATP on pyruvate kinase and a significant decrease in the [NAD+]/[NADH] concentration ratio in the cytoplasm of skeletal muscles. At the same time, activation of muscle pyruvate kinase by fructose-1,6-diphosphate was introduced into the model to allow glycolysis to provide the rate of ATP production required during muscle load activation.
期刊介绍：
Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology is an international peer reviewed journal that publishes original articles on physical, chemical, and molecular mechanisms that underlie basic properties of biological membranes and mediate membrane-related cellular functions. The primary topics of the journal are membrane structure, mechanisms of membrane transport, bioenergetics and photobiology, intracellular signaling as well as membrane aspects of cell biology, immunology, and medicine. The journal is multidisciplinary and gives preference to those articles that employ a variety of experimental approaches, basically in biophysics but also in biochemistry, cytology, and molecular biology. The journal publishes articles that strive for unveiling membrane and cellular functions through innovative theoretical models and computer simulations.
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