Photo-induced multiple charge transfer resonance of Ce-MOF for SERS detection of nucleic acid

IF 5.7 2区 化学 Q1 CHEMISTRY, ANALYTICAL
Chaoqin He, Lingling Jiang, Xichen Shi, Ying Zhuo, Ruo Yuan, Xia Yang
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Abstract

Background

Sensitive and accurate detection of important cancer markers MicroRNAs (miRNAs) is critical to prevent and treat disease. Among many detection techniques, surface-enhanced Raman scattering(SERS) has attracted much attention due to its advantages such as narrow spectral peak, low interference and non-destructive detection. Interestingly, non-noble metal SERS substrates show good prospects due to their outstanding spectral reproducibility and biocompatibility. However, the low SERS sensitivity of non-noble metal substrates also limited their detection performance. Therefore, it is crucial to design a non-noble metal substrate with high SERS sensitivity for nucleic acid detection.

Results

In this study, we found that the photo induction (30 min) of Ce-MOF has high SERS performance (abbreviated as Ce-MOF30). It is due to that photo-induction can regulate the energy level of the Ce-MOF and break the benzene-C bonds to introduce a defect energy level, which provides additional charge transfer channels. The Ce-MOF30 substrates can achieve an enhancement factor (EF) of 6.71 × 106 for Methylene blue (MB), about 7-fold higher than pristine Ce-MOF, which is the best Ce-based SERS substrate so far. Finally, a SERS detection platform was fabricated by combining the Mg2+ assisted dual signal amplification for miRNA 141 assay, and the detection limit was 1.72 fM.

Significance

This work proposed a simple photo-induction strategy to enhance SERS performance, which supplied a new detection platform for detection of nucleic acid and further expand the application of non-noble metal substrate in SERS field.

Abstract Image

Abstract Image

用于核酸SERS检测的Ce-MOF光诱导多电荷转移共振
敏感和准确地检测重要的癌症标志物MicroRNAs (miRNAs)对于预防和治疗疾病至关重要。在众多的检测技术中,表面增强拉曼散射(SERS)以其光谱峰窄、干扰小、无损检测等优点受到了广泛的关注。有趣的是,非贵金属SERS基底因其出色的光谱再现性和生物相容性而具有良好的应用前景。然而,非贵金属衬底的低SERS灵敏度也限制了它们的检测性能。因此,设计一种具有高SERS灵敏度的非贵金属底物用于核酸检测至关重要。结果本研究发现Ce-MOF的光诱导(30 min)具有较高的SERS性能(简称Ce-MOF30)。这是因为光感应可以调节Ce-MOF的能级,打破苯- c键,引入缺陷能级,从而提供额外的电荷转移通道。Ce-MOF30底物对亚甲基蓝(MB)的增强因子(EF)为6.71 × 106,比原始Ce-MOF高出约7倍,是目前为止性能最好的ce基SERS底物。最后,结合Mg2+辅助双信号扩增构建了miRNA 141检测的SERS检测平台,检测限为1.72 fM。本工作提出了一种简单的光感应策略来增强SERS性能,为核酸检测提供了新的检测平台,进一步拓展了非贵金属底物在SERS领域的应用。
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来源期刊
Analytica Chimica Acta
Analytica Chimica Acta 化学-分析化学
CiteScore
10.40
自引率
6.50%
发文量
1081
审稿时长
38 days
期刊介绍: Analytica Chimica Acta has an open access mirror journal Analytica Chimica Acta: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Analytica Chimica Acta provides a forum for the rapid publication of original research, and critical, comprehensive reviews dealing with all aspects of fundamental and applied modern analytical chemistry. The journal welcomes the submission of research papers which report studies concerning the development of new and significant analytical methodologies. In determining the suitability of submitted articles for publication, particular scrutiny will be placed on the degree of novelty and impact of the research and the extent to which it adds to the existing body of knowledge in analytical chemistry.
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