Assessing cognitive functions in non-neuropsychiatric childhood systemic lupus erythematosus: Cross-sectional study

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research Pub Date : 2025-02-01 DOI:10.1016/j.jpsychores.2024.112027

Emil Aliyev , Ecem Selin Akbas Aliyev , Selcan Demir , Mubeccel Yeniada Kirseven , Cihat Celik , Ozlem Kahraman Erkus , Halime Tuna Cak Esen , Ebru Cengel Kultur , Banu Anlar , Seza Ozen , Yelda Bilginer

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引用次数: 0

Abstract

Objectives

Systemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by multisystem, including neuropsychiatric, involvement. The nervous system is affected in 20–27 % of patients within approximately two years after diagnosis. This study aimed to examine neurocognitive impairment in childhood-onset SLE (cSLE) patients before the development of any neurological, psychiatric, or cognitive manifestations.

Methods

The study included 98 children and adolescents. Of these, 34 (35 %) were cSLE groups, and the remaining formed two control groups: 31 (31 %) oligoarticular Juvenile Idiopathic Arthritis (oJIA) patients served as a “patient control” group, and 33 (34 %) healthy participants socio-demographically matched to the cSLE and oJIA patients formed the healthy control (HC) group. None of the subjects in the study exhibited neurological or psychiatric symptoms.

Results

The Wechsler Intelligence Scale for Children-IV (WISC-IV) was applied to all groups. Test results showed that the Perceptual Reasoning Index Score (PRIS) was significantly lower in cSLE than in HC (F(2, 95) = 3.365, p = 0.042, Tukey HSD: p = 0.01). ‘Comprehension’ subtest scores were significantly lower in the cSLE group compared to the HC group (H(2) = 8.133, p = 0.017; U = 352.5, p = 0.009). Similarly, ‘symbol search’ subtest scores were significantly lower in the cSLE group compared to the HC group (F(2, 95) = 3.545, p = 0.036, Tukey HSD: p = 0.014).

Conclusion

Our results revealed that cSLE may have neurocognitive impairment without presenting any symptoms. Early detection is possible with the neurocognitive test WISC-IV. These results support the inclusion of objective neurocognitive assessment methods into the routine clinical follow-up of childhood-onset SLE.

查看原文本刊更多论文

评估儿童非神经精神性系统性红斑狼疮的认知功能：横断面研究。

目的：系统性红斑狼疮（SLE）是一种多系统自身免疫性疾病，包括神经精神系统。20- 27%的患者在诊断后大约两年内神经系统受到影响。本研究旨在检查儿童期SLE （cSLE）患者在出现任何神经、精神或认知表现之前的神经认知障碍。方法：研究对象为98名儿童和青少年。其中34例（35%）为cSLE组，其余组成两个对照组：31例（31%）少关节幼年特发性关节炎（oJIA）患者作为“患者对照组”，33例（34%）社会人口统计学上与cSLE和oJIA患者相匹配的健康参与者组成健康对照组（HC）组。研究中没有受试者表现出神经或精神症状。结果：各组采用韦氏儿童智力量表（WISC-IV）。结果显示，cSLE患者的知觉推理指数得分（PRIS）显著低于HC患者（F(2,95) = 3.365, p = 0.042, Tukey HSD: p = 0.01）。cSLE组“理解”子测试得分显著低于HC组(H(2) = 8.133, p = 0.017；U = 352.5, p = 0.009)。同样，与HC组相比，cSLE组的“符号搜索”子测试得分显著低于HC组（F(2,95) = 3.545, p = 0.036, Tukey HSD: p = 0.014）。结论：我们的研究结果显示，cSLE可能有神经认知障碍，但没有任何症状。神经认知测试WISC-IV可以早期发现。这些结果支持将客观的神经认知评估方法纳入儿童期SLE的常规临床随访。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Psychosomatic Research 医学-精神病学

CiteScore

7.40

自引率

6.40%

发文量

314

审稿时长

6.2 weeks

期刊介绍： The Journal of Psychosomatic Research is a multidisciplinary research journal covering all aspects of the relationships between psychology and medicine. The scope is broad and ranges from basic human biological and psychological research to evaluations of treatment and services. Papers will normally be concerned with illness or patients rather than studies of healthy populations. Studies concerning special populations, such as the elderly and children and adolescents, are welcome. In addition to peer-reviewed original papers, the journal publishes editorials, reviews, and other papers related to the journal''s aims.