Alessa Fischer, Hanna Remde, Christina Pamporaki, Ulrich Dischinger, Nicole Bechmann, Mercedes Robledo, Katharina Wang, Diana Vetter, José Oberholzer, Grégoire B Morand, Simon Andreas Mueller, Alexander Huber, Ralph Fritsch, Sven Gruber, Constanze Hantel, Kathrin Zitzmann, Martin Reincke, Christoph J Auernhammer, Karel Pacak, Ashley B Grossman, Felix Beuschlein, Svenja Nölting
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引用次数: 0
Abstract
Context: Pheochromocytomas and paragangliomas (PPGLs) are rare endocrine tumors that frequently produce catecholamines. Catecholamine-induced cardiometabolic complications substantially contribute to increased morbidity and mortality in PPGL patients prior to surgical resection.
Objective: To determine whether markers of elevated cardiometabolic risk persist in patients following PPGL resection.
Design: Retrospective analysis of a multicenter cohort of patients with PPGLs participating in the prospective ProsPheo study and the ENS@T registry.
Methods: Cardiometabolic risk factors, including glycemic status, dyslipidemia, and BMI, were assessed in patients with PPGL at diagnosis and during follow-up. Patients with a history of resected PPGL were compared to a control group with non-functioning adrenal adenomas (NFAA) from the ENS@T registry.
Results: Patients with a present PPGL or a history of PPGL (n=188), a metastatic PPGL (n=27) or a known susceptibility gene pathogenic variant (PV) for the development of PPGL without a history of PPGL (n=44), were included. We compared the asymptomatic PV carriers to patients with a history of PPGL: those with a history of PPGL showed a significantly higher prevalence of hyperglycemic disorders (p=0.013) compared to asymptomatic PV carriers. In patients with a history of PPGL and at least 12 months of follow-up post-surgery (n=113), the prevalence of hyperglycemic disorders (p<0.001), as well as the mean HbA1c (5.63%, SD 0.43%), were significantly higher, compared to a control group with NFAA (n=76) of similar age and BMI (HbA1c 5.45%, SD 0.40%; p = 0.004).
Conclusions: Glycemic disturbances persist long-term after the resection of PPGL.
期刊介绍：
The Journal of Clinical Endocrinology & Metabolism is the world"s leading peer-reviewed journal for endocrine clinical research and cutting edge clinical practice reviews. Each issue provides the latest in-depth coverage of new developments enhancing our understanding, diagnosis and treatment of endocrine and metabolic disorders. Regular features of special interest to endocrine consultants include clinical trials, clinical reviews, clinical practice guidelines, case seminars, and controversies in clinical endocrinology, as well as original reports of the most important advances in patient-oriented endocrine and metabolic research. According to the latest Thomson Reuters Journal Citation Report, JCE&M articles were cited 64,185 times in 2008.
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