Superselective embolic particle guidance in vessel networks via shape-adaptive acoustic manipulation.

IF 14.7 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Yucheng Luo, Qiu Yin, Keke Chen, Zhaoyu Deng, Xiaozhou Liu, Yinning Zhou, Benpeng Zhu, Wenming Zhang, Zhichao Ma
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引用次数: 0

Abstract

Interventional embolization has been widely used as a clinical cancer therapy, which deactivates the tumors by occluding their blood supply vessels. However, conventional methods lack active control over the embolic particles, thus having a limited selectivity of millimeter-scale vessels and the issue of missing embolization. Here, we propose an ultrasound-based method for embolic particle control in submillimeter vessels. The biocompatible ultrasound generated from an extrasomatic source can transmit through biological tissues, and exert forces on the intravital embolic particles. We show that the particles, influenced by these forces, are steerable to the target branch at vascular bifurcations. By modulating the ultrasound to adapt the vascular bifurcation distribution, the particles flowing in the micro-vessel networks are steered to the target branch and embolize it. The acoustic steering within ex vivo and in vivo models both verify the potential of this non-invasive particle control for precise and safe interventional therapy.

基于形状自适应声学操纵的血管网络超选择性栓塞粒子引导。
介入栓塞是一种通过阻断肿瘤供血血管使肿瘤失活的治疗方法,已被广泛应用于临床。然而,传统方法缺乏对栓塞颗粒的主动控制,因此对毫米级血管的选择性有限,并且存在遗漏栓塞的问题。在这里,我们提出了一种基于超声的亚毫米血管栓塞颗粒控制方法。由体外源产生的生物相容性超声可以通过生物组织传播,并对生命栓塞颗粒施加力。我们表明,受这些力的影响,粒子在血管分叉处可转向目标分支。通过调制超声以适应血管分叉的分布,使微血管网络中的微粒流向目标分支并栓塞。在离体和体内模型中的声学控制都验证了这种非侵入性粒子控制在精确和安全的介入治疗中的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Nature Communications
Nature Communications Biological Science Disciplines-
CiteScore
24.90
自引率
2.40%
发文量
6928
审稿时长
3.7 months
期刊介绍: Nature Communications, an open-access journal, publishes high-quality research spanning all areas of the natural sciences. Papers featured in the journal showcase significant advances relevant to specialists in each respective field. With a 2-year impact factor of 16.6 (2022) and a median time of 8 days from submission to the first editorial decision, Nature Communications is committed to rapid dissemination of research findings. As a multidisciplinary journal, it welcomes contributions from biological, health, physical, chemical, Earth, social, mathematical, applied, and engineering sciences, aiming to highlight important breakthroughs within each domain.
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