Thalamo-insular cortex connections in the rat and human

IF 2.5 4区医学 Q3 NEUROSCIENCES

Neuroscience Letters Pub Date : 2025-01-31 DOI:10.1016/j.neulet.2024.138111

Mazhar Özkan , Damlasu Altınöz , Elif Erkan , Yasin Celal Güneş , Oktay Algın , Safiye Çavdar

{"title":"Thalamo-insular cortex connections in the rat and human","authors":"Mazhar Özkan , Damlasu Altınöz , Elif Erkan , Yasin Celal Güneş , Oktay Algın , Safiye Çavdar","doi":"10.1016/j.neulet.2024.138111","DOIUrl":null,"url":null,"abstract":"<div><div>The insular cortex (ICx) has a role in large a variety of functions. Thalamus plays an important role in modulating cortical functions. The present study aims to show thalamic-ICx connections using the fluoro-gold (FG) tracing method in rats and diffusion tensoring-based tractography (DTI) in humans. Wistar albino rats were pressure injected with the FG tracer into the anterior and posterior ICx. The DTI data were obtained from the Human Connectome Project database. Our findings showed that the thalamic-ICx connections were strictly ipsilateral in the rat, however, bilateral connections were present in humans. The anterior ICx was connected to the paraventricular, centromedial, paracentral, centrolateral, ventral posteromedial, and medial geniculate thalamic nuclei. The posterior ICx was connected to the centromedian, parafasicular, renuence, lateral, posterior, ventral posteromedial, and medial geniculate thalamic nuclei. The DTI in humans corresponded with the results of the experimental study on rats. The results of the current study may provide an understanding of how thalamic nuclei may contribute to higher-order ICx functions. The ipsilateral connections in the rat and bilateral in humans may provide insights into anatomical evolution and functional differences of the ICx circuit in humans and rats. Further, stimulation of the thalamus can be a potential target for treating or modulating ICx functions such as anxiety, depression, and certain chronic pain conditions.</div></div>","PeriodicalId":19290,"journal":{"name":"Neuroscience Letters","volume":"847 ","pages":"Article 138111"},"PeriodicalIF":2.5000,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuroscience Letters","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0304394024004907","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NEUROSCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

The insular cortex (ICx) has a role in large a variety of functions. Thalamus plays an important role in modulating cortical functions. The present study aims to show thalamic-ICx connections using the fluoro-gold (FG) tracing method in rats and diffusion tensoring-based tractography (DTI) in humans. Wistar albino rats were pressure injected with the FG tracer into the anterior and posterior ICx. The DTI data were obtained from the Human Connectome Project database. Our findings showed that the thalamic-ICx connections were strictly ipsilateral in the rat, however, bilateral connections were present in humans. The anterior ICx was connected to the paraventricular, centromedial, paracentral, centrolateral, ventral posteromedial, and medial geniculate thalamic nuclei. The posterior ICx was connected to the centromedian, parafasicular, renuence, lateral, posterior, ventral posteromedial, and medial geniculate thalamic nuclei. The DTI in humans corresponded with the results of the experimental study on rats. The results of the current study may provide an understanding of how thalamic nuclei may contribute to higher-order ICx functions. The ipsilateral connections in the rat and bilateral in humans may provide insights into anatomical evolution and functional differences of the ICx circuit in humans and rats. Further, stimulation of the thalamus can be a potential target for treating or modulating ICx functions such as anxiety, depression, and certain chronic pain conditions.

Abstract Image

查看原文本刊更多论文

大鼠和人类的丘脑-岛叶皮层连接。

岛叶皮层（ICx）在许多功能中起着重要作用。丘脑在调节皮质功能中起着重要作用。本研究旨在利用大鼠的氟金（FG）示踪方法和人类的基于扩散张量的神经束图（DTI）显示丘脑- icx的连接。将FG示踪剂压入Wistar白化大鼠的前、后ICx。DTI数据来源于Human Connectome Project数据库。我们的研究结果表明，大鼠的丘脑- icx连接是严格同侧的，然而，人类的双侧连接存在。前ICx与室旁核、中央内侧核、中央旁核、中央外侧核、腹侧后内侧核和内侧膝状丘脑核相连。后ICx连接丘脑正中核、束旁核、后核、外侧核、后核、腹侧核和内侧膝状核。人类的DTI与大鼠的实验研究结果一致。目前的研究结果可能提供了如何丘脑核可能有助于高阶ICx功能的理解。大鼠的同侧连接和人类的双侧连接可能为人类和大鼠ICx回路的解剖进化和功能差异提供了见解。此外，刺激丘脑可以成为治疗或调节ICx功能的潜在目标，如焦虑、抑郁和某些慢性疼痛状况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Neuroscience Letters 医学-神经科学

CiteScore

5.20

自引率

0.00%

发文量

408

审稿时长

50 days

期刊介绍： Neuroscience Letters is devoted to the rapid publication of short, high-quality papers of interest to the broad community of neuroscientists. Only papers which will make a significant addition to the literature in the field will be published. Papers in all areas of neuroscience - molecular, cellular, developmental, systems, behavioral and cognitive, as well as computational - will be considered for publication. Submission of laboratory investigations that shed light on disease mechanisms is encouraged. Special Issues, edited by Guest Editors to cover new and rapidly-moving areas, will include invited mini-reviews. Occasional mini-reviews in especially timely areas will be considered for publication, without invitation, outside of Special Issues; these un-solicited mini-reviews can be submitted without invitation but must be of very high quality. Clinical studies will also be published if they provide new information about organization or actions of the nervous system, or provide new insights into the neurobiology of disease. NSL does not publish case reports.