Association between Bioelectrical Impedance Parameters, Magnetic Resonance Imaging Muscle Parameters, and Fatty Liver Severity in Children and Adolescents.

IF 3.4 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Gut and Liver Pub Date : 2025-01-15 Epub Date: 2025-01-03 DOI:10.5009/gnl240342

Kyungchul Song, Eun Gyung Seol, Eunju Lee, Hye Sun Lee, Hana Lee, Hyun Wook Chae, Hyun Joo Shin

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引用次数: 0

Abstract

Background/aims: To evaluate the associations between pediatric fatty liver severity, bioelectrical impedance analysis (BIA), and magnetic resonance imaging parameters, including total psoas muscle surface area (tPMSA) and paraspinal muscle fat (PMF).

Methods: Children and adolescents who underwent BIA and liver magnetic resonance imaging between September 2022 and November 2023 were included. Linear regression analyses identified predictors of liver proton density fat fraction (PDFF) including BIA parameters, tPMSA, and PMF. Ordinal logistic regression analysis identified the association between these parameters and fatty liver grades. Pearson's correlation coefficients were used to evaluate the relationships between tPMSA and muscle-related BIA parameters, and between PMF and fat-related BIA parameters.

Results: Overall, 74 participants aged 8 to 16 years were included in the study. In the linear regression analyses, the percentage of body fat was positively associated with PDFF in all participants, whereas muscle-related BIA parameters were negatively associated with PDFF in participants with obesity. PMF and the PMF index were positively associated with PDFF in normalweight and overweight participants. In the ordinal logistic regression, percentage of body fat was positively associated with fatty liver grade in normal-weight and overweight participants and those with obesity, whereas muscle-related BIA parameters were negatively associated with fatty liver grade in participants with obesity. The PMF index was positively associated with fatty liver grade in normal/overweight participants. In the Pearson correlation analysis, muscle-related BIA parameters were correlated with tPMSA, and the fat-related BIA parameters were correlated with PMF.

Conclusions: BIA parameters and PMF are potential screening tools for assessing fatty liver in children.

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儿童和青少年的生物电阻抗参数、磁共振成像肌肉参数和脂肪肝严重程度之间的关系。

背景/目的：评估小儿脂肪肝严重程度、生物电阻抗分析（BIA）和磁共振成像参数（包括腰肌总表面积（tPMSA）和棘旁肌脂肪（PMF））之间的关系。方法：纳入2022年9月至2023年11月期间接受BIA和肝脏磁共振成像的儿童和青少年。线性回归分析确定了肝质子密度脂肪分数（PDFF）的预测因子，包括BIA参数、tPMSA和PMF。有序逻辑回归分析确定了这些参数与脂肪肝分级之间的关联。采用Pearson相关系数评价tPMSA与肌肉相关BIA参数、PMF与脂肪相关BIA参数之间的关系。结果：总体而言，74名8至16岁的参与者被纳入研究。在线性回归分析中，所有参与者的体脂百分比与PDFF呈正相关，而肥胖参与者的肌肉相关BIA参数与PDFF呈负相关。在正常体重和超重的参与者中，PMF和PMF指数与PDFF呈正相关。在有序逻辑回归中，体脂百分比与正常体重、超重和肥胖参与者的脂肪肝等级呈正相关，而与肌肉相关的BIA参数与肥胖参与者的脂肪肝等级呈负相关。在正常/超重参与者中，PMF指数与脂肪肝分级呈正相关。Pearson相关分析中，肌肉相关BIA参数与tPMSA相关，脂肪相关BIA参数与PMF相关。结论：BIA参数和PMF是评估儿童脂肪肝的潜在筛查工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gut and Liver 医学-胃肠肝病学

CiteScore

7.50

自引率

8.80%

发文量

119

审稿时长

6-12 weeks

期刊介绍： Gut and Liver is an international journal of gastroenterology, focusing on the gastrointestinal tract, liver, biliary tree, pancreas, motility, and neurogastroenterology. Gut and Liver delivers up-to-date, authoritative papers on both clinical and research-based topics in gastroenterology. The Journal publishes original articles, case reports, brief communications, letters to the editor and invited review articles in the field of gastroenterology. The Journal is operated by internationally renowned editorial boards and designed to provide a global opportunity to promote academic developments in the field of gastroenterology and hepatology. Gut and Liver is jointly owned and operated by 8 affiliated societies in the field of gastroenterology, namely: the Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, the Korean College of Helicobacter and Upper Gastrointestinal Research, the Korean Association for the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, the Korean Pancreatobiliary Association, and the Korean Society of Gastrointestinal Cancer.