High-Energy Nutrition in Hospitalised Paediatric Patients With Congenital Heart Disease: A Systematic Review and Meta-Analysis

IF 1.6 4区医学 Q2 PEDIATRICS

Journal of paediatrics and child health Pub Date : 2025-01-02 DOI:10.1111/jpc.16767

Lorhayne Kerley Capuchinho Scalioni Galvao, Ana Clara Felix de Farias Santos, Fernanda Valeriano Zamora, Nicole dos Santos Pimenta, João Pedro Costa Esteves Almuinha Salles, Isabella Guzzardi Hable

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引用次数: 0

Abstract

Aims

Congenital heart disease (CHD) is a significant cause of growth failure and neonatal mortality worldwide, and requirement-focused nutritional management can deeply impact the prognosis. Despite multiple trials, there is no published meta-analysis on the impact of high-energy nutrition in this population.

Methods

We searched PubMed, Embase and Cochrane Central for RCTs comparing high-energy to standard formulas in hospitalised patients. We computed mean differences (MDs) for continuous outcomes and odds ratios (ORs) for binary endpoints, with 95% confidence intervals (CIs).

Results

Five studies comprising 276 patients were included, of whom 139 (50.4%) received the high-energy formula. Compared with the standard, they had higher weight gain (MD 276.37; 95% CI 56.29, 496.46). Despite no statistical significance, the length of hospital stay (MD −3.51; 95% CI −7.33, 0.3) tends to be shorter. There were no significant differences regarding the length of ICU stay (MD −10.32; 95% CI −58.04, 37.40) and mechanical ventilation (MD −19.54; 95% CI −47.81, 8.73). The presence of side effects (OR 1.82; 95% CI 0.58, 5.7; p = 0.3) was one of the outcomes most reported as better in the control group, but overall, there's no significant difference.

Conclusion

Our findings suggest the high-energy formula may be superior to control considering weight gain. In addition, the presence of side effects was not significantly different between groups.

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高能量营养对住院儿科先天性心脏病患者的影响：一项系统综述和荟萃分析

目的：先天性心脏病（CHD）是全球范围内导致新生儿生长衰竭和死亡的重要原因，以需求为重点的营养管理可以深刻影响预后。尽管进行了多次试验，但没有发表过关于高能量营养对这一人群影响的荟萃分析。方法：我们检索了PubMed， Embase和Cochrane Central，以比较住院患者的高能配方和标准配方的rct。我们计算了连续结局的平均差异（MDs）和二元终点的优势比（ORs），并采用95%置信区间（ci）。结果：纳入5项研究共276例患者，其中139例（50.4%）采用高能配方。与标准组相比，他们的体重增加更高(MD 276.37；95% ci 56.29, 496.46)。住院时间(MD -3.51；95% CI -7.33, 0.3)往往较短。两组ICU住院时间差异无统计学意义(MD -10.32；95% CI -58.04, 37.40)和机械通气(MD -19.54；95% ci -47.81, 8.73)。存在副作用(OR 1.82；95% ci 0.58, 5.7；P = 0.3)是对照组中报告的最好的结果之一，但总体而言，没有显著差异。结论：我们的研究结果表明，考虑到体重增加，高能配方可能优于控制配方。此外，副作用的存在在两组之间没有显著差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of paediatrics and child health 医学-小儿科

CiteScore

2.90

自引率

5.90%

发文量

487

审稿时长

3-6 weeks

期刊介绍： The Journal of Paediatrics and Child Health publishes original research articles of scientific excellence in paediatrics and child health. Research Articles, Case Reports and Letters to the Editor are published, together with invited Reviews, Annotations, Editorial Comments and manuscripts of educational interest.