Regulatory Roles of SWI/SNF Chromatin Remodeling Complexes in Immune Response and Inflammatory Diseases.

IF 8.4 2区医学 Q1 ALLERGY

Clinical Reviews in Allergy & Immunology Pub Date : 2024-12-30 DOI:10.1007/s12016-024-09011-4

Shunan Sun, Yu Chen, Yuzhen Ouyang, Zhenwei Tang

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引用次数: 0

Abstract

The switch/sucrose non-fermentable (SWI/SNF) chromatin remodeling complexes (also referred to as BAF complexes) are composed of multiple subunits, which regulate the nucleosome translocation and chromatin accessibility. In recent years, significant advancements have been made in understanding mutated genes encoding subunits of the SWI/SNF complexes in cancer biology. Nevertheless, the role of SWI/SNF complexes in immune response and inflammatory diseases continues to attract significant attention. This review presents a summary of the significant functions of SWI/SNF complexes during the overall process from the development to the activation of innate and adaptive immune cells. In addition, the correlation between various SWI/SNF subunits and diverse inflammatory diseases is explored. Further investigations are warranted in terms of the mechanism of SWI/SNF complexes' preference for binding sites and opposite pro-/anti-inflammatory effects. In conclusion, further efforts are needed to evaluate the druggability of targeting SWI/SNF complexes in inflammatory diseases, and we hope this review will inspire the development of novel immune modulators in clinical practice.

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开关/蔗糖不发酵（SWI/SNF）染色质重塑复合物（也称为BAF复合物）由多个亚基组成，可调节核小体易位和染色质可及性。近年来，人们在了解癌症生物学中编码 SWI/SNF 复合物亚基的突变基因方面取得了重大进展。然而，SWI/SNF 复合物在免疫反应和炎症性疾病中的作用仍然备受关注。本综述总结了 SWI/SNF 复合物在先天性和适应性免疫细胞从发育到激活的整个过程中的重要功能。此外，还探讨了各种 SWI/SNF 亚基与各种炎症疾病之间的相关性。关于 SWI/SNF 复合物对结合位点的偏好机制以及相反的促炎/抗炎作用，还有待进一步研究。总之，我们需要进一步努力评估针对 SWI/SNF 复合物治疗炎症性疾病的可药性，希望这篇综述能对临床实践中新型免疫调节剂的开发有所启发。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Reviews in Allergy & Immunology 医学-过敏

CiteScore

22.30

自引率

1.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical Reviews in Allergy & Immunology is a scholarly journal that focuses on the advancement of clinical management in allergic and immunologic diseases. The journal publishes both scholarly reviews and experimental papers that address the current state of managing these diseases, placing new data into perspective. Each issue of the journal is dedicated to a specific theme of critical importance to allergists and immunologists, aiming to provide a comprehensive understanding of the subject matter for a wide readership. The journal is particularly helpful in explaining how novel data impacts clinical management, along with advancements such as standardized protocols for allergy skin testing and challenge procedures, as well as improved understanding of cell biology. Ultimately, the journal aims to contribute to the improvement of care and management for patients with immune-mediated diseases.