Nomogram model based on serum chitotriosidase activity to predict coronary artery aneurysm in Kawasaki disease.

IF 2 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Coronary artery disease Pub Date : 2025-09-01 Epub Date: 2025-07-30 DOI:10.1097/MCA.0000000000001492

Rui Wang, Dan Wei, Min Gu, Jiao Mi, Xing Hu, Wanli Pu

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引用次数: 0

Abstract

Objective: Kawasaki disease (KD) is a common children's disease with unknown etiology, which easily involves coronary artery and causes serious cardiovascular sequelae. The purpose was to investigate the relationship between chitotriosidase activity and coronary artery aneurysm (CAA) and develop and validate a nomogram to predict CAA in KD patients.

Methods: A total of 338 KD patients were included in this study. Differences analysis compared baseline characteristics and multivariate logistic regression analysis to determine independent risk factors for CAA in KD patients. Based on this independent risk factor, the nomogram was constructed and validated.

Results: Of 338 KD patients, 107 patients developed CAA. Multivariate logistic regression analysis identified that low-density lipoprotein (LDL) [odds ratio (OR):1.456, 95% confidence interval (CI): 1.062-1.996], age (OR: 0.986, 95% CI: 0.974-0.998), neutrophil-to-lymphocyte ratio (NLR) (OR: 1.098, 95% CI: 1.020-1.182), and chitotriosidase activity (OR: 1.115, 95% CI: 1.111-1.192) were independent predictors for CAA. The nomogram was established based on serum chitotriosidase activity and clinical characteristics, and this nomogram has demonstrated to be of potential value in clinical practice using the receiver operating characteristic curve, calibration curve, and decision curve analysis.

Conclusion: LDL, age, NLR, and chitotriosidase activity were independent risk factors for CAA. Based on this independent risk factor, the nomogram was constructed to guide clinicians to effectively predict CAA and adopt appropriate interventions such as more aggressive anti-inflammatory and more frequent follow-up.

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基于血清壳三醇苷酶活性的Nomogram模型预测川崎病冠状动脉瘤。

目的：川崎病（Kawasaki disease， KD）是一种病因不明的儿童常见病，易累及冠状动脉，引起严重的心血管后遗症。目的是研究壳三醇苷酶活性与冠状动脉动脉瘤（CAA）的关系，并开发和验证预测KD患者CAA的nomogram。方法：本研究共纳入338例KD患者。差异分析比较了基线特征和多因素logistic回归分析，以确定KD患者CAA的独立危险因素。基于这一独立的危险因素，构建了模态图并进行了验证。结果：338例KD患者中，107例发生CAA。多因素logistic回归分析发现，低密度脂蛋白（LDL）[比值比（OR）：1.456, 95%可信区间（CI）： 1.062-1.996]、年龄（OR: 0.986, 95% CI: 0.974-0.998）、中性粒细胞与淋巴细胞比值（NLR）（OR: 1.098, 95% CI: 1.020-1.182）和壳三酸苷酶活性（OR: 1.115, 95% CI: 1.111-1.192）是CAA的独立预测因子。基于血清壳三醇苷酶活性和临床特征建立了nomogram，并通过对受试者工作特征曲线、校准曲线和决策曲线的分析，证明了该nomogram具有潜在的临床应用价值。结论：LDL、年龄、NLR和壳三醇苷酶活性是CAA的独立危险因素。基于这一独立的危险因素，构建nomogram来指导临床医生有效预测CAA，并采取更积极的抗炎和更频繁的随访等适当的干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Coronary artery disease 医学-外周血管病

CiteScore

2.50

自引率

0.00%

发文量

190

审稿时长

6-12 weeks

期刊介绍： Coronary Artery Disease welcomes reports of original research with a clinical emphasis, including observational studies, clinical trials, translational research, novel imaging, pharmacology and interventional approaches as well as advances in laboratory research that contribute to the understanding of coronary artery disease. Each issue of Coronary Artery Disease is divided into four areas of focus: Original Research articles, Review in Depth articles by leading experts in the field, Editorials and Images in Coronary Artery Disease. The Editorials will comment on selected original research published in each issue of Coronary Artery Disease, as well as highlight controversies in coronary artery disease understanding and management. Submitted artcles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.