Angiotensin II type-1 receptor autoantibodies and effects in neonates of women with preeclampsia.

IF 2.8 2区 医学 Q1 OBSTETRICS & GYNECOLOGY
Laure Ponthier, Chahrazed El Hamel, Perrine Coste Mazeau, Sophie Martinez, Sarah Wehbe, Rachel Froget, Catherine Yardin, Vincent Guigonis
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引用次数: 0

Abstract

Background: Maternal agonistic autoantibodies against the angiotensin II type 1 receptor (AT1-AAs) have been implicated in the pathophysiology of preeclampsia, but their presence in their offsprings and their possible neonatal effects have not been specifically explored. This prospective study aimed to evaluate the presence of AT1-AAs and their potential clinical effects in neonates of AT1-AAs positive mothers.

Methods: Women with preeclampsia and their neonates were included. Blood samples were collected in order to search for AT1-AAs.

Results: AT1-AA determination was positive in 35 out of 64 of the studied women (54.7%). Thirty one newborns from the group of AT1-AA positive women were included and 22 (71%) were AT1-AA positive. The mothers' and children's AT1-AAs titers were significantly correlated. The 33 newborns from the group of AT1-AA negative women were all negative for AT1-AAs. Regarding the clinical data of newborns (birth weight, percentile of weight, gestational age, Apgar score at five minutes, mechanical or noninvasive ventilation), no significant difference was observed between the children with or without detected AT1-AAs.

Conclusion: Even though AT1-AAs are detected in newborns of positive mothers during the first days of life, no specific clinical signs seem to be associated with the presence of these antibodies.

血管紧张素II型1受体自身抗体及其对子痫前期妇女新生儿的影响。
背景:母体抗血管紧张素II型1受体(AT1-AAs)的激动性自身抗体与子痫前期的病理生理有关,但它们在后代中的存在及其可能对新生儿的影响尚未被专门探讨。本前瞻性研究旨在评估AT1-AAs阳性母亲的新生儿中AT1-AAs的存在及其潜在的临床影响。方法:以先兆子痫妇女及其新生儿为研究对象。采集血样,寻找AT1-AAs。结果:64例女性中有35例(54.7%)检测出AT1-AA阳性。从AT1-AA阳性妇女组中选取31例新生儿,其中22例(71%)为AT1-AA阳性。母亲与儿童的AT1-AAs滴度有显著相关。AT1-AA阴性组33例新生儿均为AT1-AA阴性。关于新生儿的临床资料(出生体重、体重百分位数、胎龄、5分钟Apgar评分、机械或无创通气),检测到AT1-AAs的儿童与未检测到AT1-AAs的儿童之间无显著差异。结论:尽管AT1-AAs在阳性母亲出生后的第一天检测到,但似乎没有特定的临床症状与这些抗体的存在相关。
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来源期刊
BMC Pregnancy and Childbirth
BMC Pregnancy and Childbirth OBSTETRICS & GYNECOLOGY-
CiteScore
4.90
自引率
6.50%
发文量
845
审稿时长
3-8 weeks
期刊介绍: BMC Pregnancy & Childbirth is an open access, peer-reviewed journal that considers articles on all aspects of pregnancy and childbirth. The journal welcomes submissions on the biomedical aspects of pregnancy, breastfeeding, labor, maternal health, maternity care, trends and sociological aspects of pregnancy and childbirth.
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