Negligible Long-Term Impact of Nonlinear Growth Dynamics on Heterogeneity in Models of Cancer Cell Populations.

Abstract

Linear compartmental models are often employed to capture the change in cell type composition of cancer cell populations. Yet, these populations usually grow in a nonlinear fashion. This begs the question of how linear compartmental models can successfully describe the dynamics of cell types. Here, we propose a general modeling framework with a nonlinear part capturing growth dynamics and a linear part capturing cell type transitions. We prove that dynamics in this general model are asymptotically equivalent to those governed only by its linear part under a wide range of assumptions for nonlinear growth.