Efferocytosis: The Janus-Faced Gatekeeper of Aging and Tumor Fate

IF 7.8 1区医学 Q1 Biochemistry, Genetics and Molecular Biology

Aging Cell Pub Date : 2025-01-03 DOI:10.1111/acel.14467

Zaoqu Liu, Yan Li, Yuqing Ren, Jingqi Chen, Siyuan Weng, Zhaokai Zhou, Peng Luo, Quan Chen, Hui Xu, Yuhao Ba, Anning Zuo, Shutong Liu, Yuyuan Zhang, Teng Pan, Xinwei Han

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Abstract

From embryogenesis to aging, billions of cells perish daily in mammals. The multistep process by which phagocytes engulf these deceased cells without eliciting an inflammatory response is called efferocytosis. Despite significant insights into the fundamental mechanisms of efferocytosis, its implications in disorders such as aging and cancer remain elusive. Upon summarizing and analyzing existing studies on efferocytosis, it becomes evident that efferocytosis is our friend in resolving inflammation, yet it transforms into our foe by facilitating tumor development and metastasis. This review illuminates recent discoveries regarding the emerging mechanisms of efferocytosis in clearing apoptotic cells, explores its connections with aging, examines its influence on tumor development and metastasis, and identifies the regulatory factors of efferocytosis within the tumor microenvironment. A comprehensive understanding of these efferocytosis facets offers insights into crucial physiological and pathophysiological processes, paving the way for innovative therapeutic approaches to combat aging and cancer.

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Efferocytosis：衰老和肿瘤命运的双面守门人。

从胚胎发育到衰老，哺乳动物每天都有数十亿细胞死亡。吞噬细胞吞噬这些死亡细胞而不引起炎症反应的多步骤过程被称为efferocytosis。尽管对efferocytosis的基本机制有重要的见解，但其在衰老和癌症等疾病中的意义仍然难以捉摸。在总结和分析现有的关于efferocytosis的研究后，我们发现，efferocytosis在解决炎症方面是我们的朋友，但它也会因为促进肿瘤的发展和转移而变成我们的敌人。本文综述了近年来关于efferocytosis清除凋亡细胞的新机制的发现，探讨了其与衰老的联系，研究了其对肿瘤发展和转移的影响，并确定了efferocytosis在肿瘤微环境中的调节因素。对这些efferocytosis方面的全面理解提供了对关键生理和病理生理过程的见解，为对抗衰老和癌症的创新治疗方法铺平了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Aging Cell 生物-老年医学

CiteScore

14.40

自引率

2.60%

发文量

212

审稿时长

8 weeks

期刊介绍： Aging Cell, an Open Access journal, delves into fundamental aspects of aging biology. It comprehensively explores geroscience, emphasizing research on the mechanisms underlying the aging process and the connections between aging and age-related diseases.