Women with clinically node negative breast cancer can safely avoid axillary surgery

IF 81.1 1区医学 Q1 ONCOLOGY

Nature Reviews Clinical Oncology Pub Date : 2025-01-03 DOI:10.1038/s41571-024-00982-z

Peter Sidaway

引用次数: 0

Abstract

Axillary nodal status provides important information on the prognosis of women with invasive breast cancer. However, the required sentinel lymph node biopsy sampling procedure and the associated risks of surgical complications have raised questions regarding the necessity of this procedure in women undergoing breast-conserving surgery for early stage disease. Now, data from INSEMA, a prospective, randomized, non-inferiority trial, confirm that this procedure can safely be avoided.

A total of 5,154 women with node-negative (on ultrasonography) T1 or T2 breast cancer were randomly assigned (1:4) to breast-conserving surgery without, versus with, axillary surgery. Invasive-disease-free survival (iDFS) was the primary end point.

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临床淋巴结阴性乳腺癌的妇女可以安全地避免腋窝手术

腋窝淋巴结状态为浸润性乳腺癌患者的预后提供了重要信息。然而，所需的前哨淋巴结活检取样程序和手术并发症的相关风险引起了对早期乳腺癌妇女行保乳手术的必要性的质疑。现在，来自INSEMA（一项前瞻性、随机、非劣效性试验）的数据证实，该手术可以安全地避免。共有5154名淋巴结阴性（超声检查）T1或T2乳腺癌的妇女被随机分配（1:4）到不进行腋窝手术的保乳手术组。无侵袭性疾病生存（Invasive-disease-free survival, iDFS）为主要终点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Clinical Oncology 医学-肿瘤学

CiteScore

99.40

自引率

0.40%

发文量

114

审稿时长

6-12 weeks

期刊介绍： Nature Reviews publishes clinical content authored by internationally renowned clinical academics and researchers, catering to readers in the medical sciences at postgraduate levels and beyond. Although targeted at practicing doctors, researchers, and academics within specific specialties, the aim is to ensure accessibility for readers across various medical disciplines. The journal features in-depth Reviews offering authoritative and current information, contextualizing topics within the history and development of a field. Perspectives, News & Views articles, and the Research Highlights section provide topical discussions, opinions, and filtered primary research from diverse medical journals.