Assessing the Clinical Utility of Antinuclear Antibody Titer Dilutions, Antinuclear Antibody Staining Patterns, and Other Common Laboratory Tests in Juvenile Idiopathic Arthritis.

IF 1 Q3 MEDICINE, GENERAL & INTERNAL
Cureus Pub Date : 2024-12-30 eCollection Date: 2024-12-01 DOI:10.7759/cureus.76648
Willie S Van Heerde, Michael Jutovsky
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Abstract

Chronic musculoskeletal pain in pediatric patients can be challenging to diagnose, particularly in the absence of overt signs of autoimmune disease, as these episodes can manifest episodically. We present a case of a 14-year-old female patient with a two-year history of episodic "bone pain," morning stiffness, and infrequent fever and fatigue. Laboratory testing revealed an antinuclear antibody (ANA) titer of 1:1280 with a nuclear homogeneous pattern and a mildly elevated erythrocyte sedimentation rate (ESR). Although the patient did not meet the criteria for juvenile idiopathic arthritis (JIA), her laboratory findings and irregular musculoskeletal pain prompted the review of literature on the diagnostic value of ANA titers, ANA staining patterns, and other common lab tests in JIA.

评估抗核抗体滴度稀释、抗核抗体染色模式和其他常见实验室检查在幼年特发性关节炎中的临床应用。
儿科患者的慢性肌肉骨骼疼痛很难诊断,特别是在没有明显的自身免疫性疾病迹象的情况下,因为这些发作可能是间歇性的。我们报告一例14岁的女性患者,有两年的偶发性“骨痛”病史,晨僵,罕见的发烧和疲劳。实验室检测显示抗核抗体(ANA)滴度为1:1280,核均质模式,红细胞沉降率(ESR)轻度升高。虽然患者不符合幼年特发性关节炎(JIA)的诊断标准,但她的实验室检查结果和不规则的肌肉骨骼疼痛促使我们对ANA滴度、ANA染色模式和其他JIA常见实验室检查的诊断价值进行文献回顾。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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