{"title":"Targeting <i>SLC7A11</i>/xCT improves radiofrequency ablation efficacy of HCC by dendritic cells mediated anti-tumor immune response.","authors":"Yuzhao Jin, Songhua Cai, Yang Zhou, Dandan Guo, Yuzhen Zeng, Wangting Xu, Yiting Sun, Yueli Shi, Zhiyong Xu, Zaoqu Liu, Peng Luo, Zhao Huang, Bufu Tang","doi":"10.1002/imt2.248","DOIUrl":null,"url":null,"abstract":"<p><p>After RFA treatment in patients with liver cancer, the expression of <i>SLC7A11</i>/xCT and the proportion of DCs in the TME were significantly increased. <i>SLC7A11</i>/xCT is a poor prognostic marker for liver cancer and is mainly expressed in DCs in the TME. Targeting xCT in DCs combined with RFA significantly enhances anti-tumor immunity, suppressing tumor growth and offering a promising strategy for improved therapeutic outcomes in liver cancer.</p>","PeriodicalId":73342,"journal":{"name":"iMeta","volume":"3 6","pages":"e248"},"PeriodicalIF":23.7000,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683471/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"iMeta","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/imt2.248","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
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Abstract
After RFA treatment in patients with liver cancer, the expression of SLC7A11/xCT and the proportion of DCs in the TME were significantly increased. SLC7A11/xCT is a poor prognostic marker for liver cancer and is mainly expressed in DCs in the TME. Targeting xCT in DCs combined with RFA significantly enhances anti-tumor immunity, suppressing tumor growth and offering a promising strategy for improved therapeutic outcomes in liver cancer.
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