A mini-invasive injectable hydrogel for temporomandibular joint osteoarthritis: Its pleiotropic effects and multiple pathways in cartilage regeneration

IF 5.5 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS

Materials Science & Engineering C-Materials for Biological Applications Pub Date : 2024-12-29 DOI:10.1016/j.bioadv.2024.214162

Xiao Xu , Jiao Sun

引用次数: 0

Abstract

There are two bottlenecks in the treatment of TMJOA (temporomandibular joint osteoarthritis): ① lacking of easy-to-use repairing materials for damaged condylar cartilage; ② local inflammation interfering with in situ regeneration. In response to them, we constructed a biomimetic tilapia type I gelatin/hyaluronic acid (TGI/HA) hydrogel in this paper. It was endowed with the capability to immunoregulate mircoenvironment and concurrently induce regeneration in multiple ways. It not only reduced excretion of ECM-degrading enzymes and inflammatory factors, therefore reversing local inflammation, but also created microenvironment conducive to reparation by acting upon macrophages and T cells. In in vivo experiments, the TGI/HA hydrogel effectively restored the damaged cartilage on rat condyle, suggesting it had potential in clinical application.

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一种用于颞下颌关节骨性关节炎的微创注射水凝胶：其软骨再生的多效性和多途径。

颞下颌关节骨性关节炎（TMJOA）的治疗存在两个瓶颈：①缺乏易于使用的髁突软骨损伤修复材料；②局部炎症干扰原位再生。为此，我们构建了一种仿生罗非鱼I型明胶/透明质酸（TGI/HA）水凝胶。它具有免疫调节微环境和多种方式诱导再生的能力。它不仅减少ecm降解酶和炎症因子的排泄，从而逆转局部炎症，而且通过作用于巨噬细胞和T细胞创造有利于修复的微环境。在体内实验中，TGI/HA水凝胶能有效修复大鼠髁上受损软骨，具有临床应用潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Materials Science & Engineering C-Materials for Biological Applications 工程技术-材料科学：生物材料

CiteScore

17.80

自引率

0.00%

发文量

501

审稿时长

27 days

期刊介绍： Biomaterials Advances, previously known as Materials Science and Engineering: C-Materials for Biological Applications (P-ISSN: 0928-4931, E-ISSN: 1873-0191). Includes topics at the interface of the biomedical sciences and materials engineering. These topics include: • Bioinspired and biomimetic materials for medical applications • Materials of biological origin for medical applications • Materials for "active" medical applications • Self-assembling and self-healing materials for medical applications • "Smart" (i.e., stimulus-response) materials for medical applications • Ceramic, metallic, polymeric, and composite materials for medical applications • Materials for in vivo sensing • Materials for in vivo imaging • Materials for delivery of pharmacologic agents and vaccines • Novel approaches for characterizing and modeling materials for medical applications Manuscripts on biological topics without a materials science component, or manuscripts on materials science without biological applications, will not be considered for publication in Materials Science and Engineering C. New submissions are first assessed for language, scope and originality (plagiarism check) and can be desk rejected before review if they need English language improvements, are out of scope or present excessive duplication with published sources. Biomaterials Advances sits within Elsevier''s biomaterials science portfolio alongside Biomaterials, Materials Today Bio and Biomaterials and Biosystems. As part of the broader Materials Today family, Biomaterials Advances offers authors rigorous peer review, rapid decisions, and high visibility. We look forward to receiving your submissions!

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