Serum cholesterol levels predict the survival in patients with idiopathic pulmonary fibrosis: A long-term follow up study

IF 3.5 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Respiratory medicine Pub Date : 2025-02-01 DOI:10.1016/j.rmed.2024.107937

Ranxun Chen, Guanning Zhong, Tong Ji, Qinghua Xu, Huarui Liu, Qingqing Xu, Lulu Chen, Jinghong Dai

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引用次数: 0

Abstract

Background

The relationship between serum lipid with idiopathic pulmonary fibrosis (IPF) required to be explored. We aim to evaluate the association of serum lipid levels with mortality in patients with IPF.

Materials and methods

This retrospective study included IPF patients with more than three years follow-up. We collected baseline demographics information, forced vital capacity (FVC)% predicted, carbon monoxide diffusion capacity (DLCO)% predicted, gender-age-physiology (GAP) index, and serum lipid levels, including triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C). We evaluate the relationship between the serum lipid levels and the disease severity, and the mortality in IPF.

Results

This study enrolled 146 patients, with the three-year survival rate of 71.23 %. The median follow-up time was 46.5 months. There was no significant difference in baseline lipid levels between the survival and non-survival group. TG levels were positively correlated with DLCO% predicted (r = 0.189, p = 0.022) and negatively correlated with GAP index (r = −0.186, p = 0.025). After adjusting for GAP index, smoking history, body mass index and the use of antifibrotic and lipid-lowering drug, lower TC levels (HR: 0.74, 95 % CI: 0.58–0.94, p = 0.013) were identified as an independent risk factor for mortality.

Conclusion

This study demonstrated that lower TC levels were associated with increased mortality in IPF. More investigations are required to explore the role of lipid metabolism in the pathogenesis of pulmonary fibrosis.

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血清胆固醇水平可预测特发性肺纤维化患者的存活率：长期随访研究

背景：血脂与特发性肺纤维化（IPF）的关系有待探讨。我们的目的是评估血脂水平与IPF患者死亡率的关系。材料与方法：回顾性研究纳入IPF患者，随访3年以上。我们收集了基线人口统计信息、预测的强制肺活量（FVC）%、预测的一氧化碳扩散能力（DLCO）%、性别-年龄-生理（GAP）指数和血脂水平，包括甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）。我们评估了血脂水平与IPF患者病情严重程度及死亡率之间的关系。结果：本研究纳入146例患者，3年生存率为71.23%。中位随访时间为46.5个月。在生存组和非生存组之间，基线脂质水平没有显著差异。TG水平与DLCO%预测值呈正相关（r= 0.189, p= 0.022），与GAP指数呈负相关（r=-0.186, p=0.025）。在调整GAP指数、吸烟史、体重指数和使用抗纤维化和降脂药物后，较低的TC水平（HR: 0.74, 95% CI: 0.58-0.94, p=0.013）被确定为死亡率的独立危险因素。结论：本研究表明，较低的TC水平与IPF死亡率增加有关。脂质代谢在肺纤维化发病机制中的作用有待进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Respiratory medicine 医学-呼吸系统

CiteScore

7.50

自引率

0.00%

发文量

199

审稿时长

38 days

期刊介绍： Respiratory Medicine is an internationally-renowned journal devoted to the rapid publication of clinically-relevant respiratory medicine research. It combines cutting-edge original research with state-of-the-art reviews dealing with all aspects of respiratory diseases and therapeutic interventions. Topics include adult and paediatric medicine, epidemiology, immunology and cell biology, physiology, occupational disorders, and the role of allergens and pollutants. Respiratory Medicine is increasingly the journal of choice for publication of phased trial work, commenting on effectiveness, dosage and methods of action.