Mesoporous Prussian blue nanoparticle neuroconduit for the biological therapy targeting oxidative stress reduction, inflammation inhibition, and nerve regeneration.

IF 10.6 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Junyi Zhu, Yijia Zhang, Yinuo Sun, Fangzheng Yu, Yang Lu, Qianqian Hu, Jiali Guo, Haijuan Zhang, Tianling Chen, Feifei Lian, Jian Wang, Xiaokun Li, Jian Xiao
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Abstract

The applications of nanomaterials in regenerative medicine encompass a broad spectrum. The functional nanomaterials, such as Prussian blue and its derivative nanoparticles, exhibit potent anti-inflammatory and antioxidant properties. By combining it with the corresponding scaffold carrier, the fusion of nanomaterials and biotherapy can be achieved, thereby providing a potential avenue for clinical treatment. The present study demonstrates the fabrication of a Mesoporous Prussian blue nanoparticles (MPBN) functionalized Inverse Opal Film (IOF) neuroconduit for peripheral nerve repair through reverse replication and freeze-drying techniques. The binding of MPBN to the neuroconduit can effectively decreasing reactive oxygen species and inflammatory factors in the vicinity of the residual nerve, thereby providing protective effects on the damaged nerve. Furthermore, comprehensive behavioral, electrophysiological, and pathological analyses unequivocally substantiate the efficacy of MPBN in increasing nerve structure regeneration and ameliorating denervation-induced myopathy. Moreover, MPBN enhances the antioxidant capacity of Schwann cells by activating the AMPK/SIRT1/PGC-1 pathway. The findings suggest that MPBN, a biocompatible nanoparticle, can safeguard damaged nerves by optimizing the microenvironment surrounding nerve cells and augmenting the antioxidant capacity of nerve cells, thereby facilitating nerve regeneration and repair. This also establishes a theoretical foundation for exploring the integration and clinical translation between nanomaterials and biotherapy.

介孔普鲁士蓝纳米颗粒神经导管用于生物治疗靶向氧化应激减少,炎症抑制和神经再生。
纳米材料在再生医学中的应用非常广泛。功能纳米材料,如普鲁士蓝及其衍生物纳米颗粒,表现出强大的抗炎和抗氧化性能。将其与相应的支架载体结合,可以实现纳米材料与生物治疗的融合,从而为临床治疗提供了一条潜在的途径。本研究通过反向复制和冷冻干燥技术,制备了一种介孔普鲁士蓝纳米颗粒(MPBN)功能化的反蛋白石膜(IOF)神经管,用于周围神经修复。MPBN与神经导管结合可有效降低残神经附近的活性氧和炎症因子,从而对受损神经起到保护作用。此外,综合行为学、电生理和病理学分析明确证实了MPBN在促进神经结构再生和改善去神经支配诱导的肌病方面的功效。此外,MPBN通过激活AMPK/SIRT1/PGC-1通路增强雪旺细胞的抗氧化能力。研究结果表明,生物相容性纳米粒子MPBN可以通过优化神经细胞周围的微环境,增强神经细胞的抗氧化能力来保护受损神经,从而促进神经的再生和修复。这也为探索纳米材料与生物疗法的融合与临床转化奠定了理论基础。
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来源期刊
Journal of Nanobiotechnology
Journal of Nanobiotechnology BIOTECHNOLOGY & APPLIED MICROBIOLOGY-NANOSCIENCE & NANOTECHNOLOGY
CiteScore
13.90
自引率
4.90%
发文量
493
审稿时长
16 weeks
期刊介绍: Journal of Nanobiotechnology is an open access peer-reviewed journal communicating scientific and technological advances in the fields of medicine and biology, with an emphasis in their interface with nanoscale sciences. The journal provides biomedical scientists and the international biotechnology business community with the latest developments in the growing field of Nanobiotechnology.
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