Modified Ratio of Tremor/Postural Instability Gait Difficulty Score as an Indicator of Short-Term Outcomes of Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease.

IF 2.5 4区医学 Q2 CLINICAL NEUROLOGY

Journal of Movement Disorders Pub Date : 2025-04-01 Epub Date: 2025-01-02 DOI:10.14802/jmd.24175

Chakradhar Reddy, Kanchana Pillai, Shejoy Joshua, Anup Nair, Harshad Chavotiya, Manas Chacko, Asha Kishore

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Abstract

Objective: The outcomes of motor and nonmotor features of Parkinson's disease (PD) following deep brain stimulation (DBS) vary among its subtypes. We tested whether preoperative motor subtyping using the modified tremor/postural instability and gait difficulty ratio (T/P ratio) could indicate the short-term motor, nonmotor and quality of life (QOL) outcomes of subthalamic nucleus (STN) DBS.

Methods: In this prospective study, 39 consecutive STN DBS patients were assessed in the drug-OFF state before surgery and subtyped according to the T/P ratio. Patients were reassessed 6 months after surgery in the stimulation ON-drug-OFF state, and the percentage changes in motor, nonmotor and QOL scores (Parkinson's Disease Quality of Life Questionnaire [PDQ-39]) were calculated.

Results: The modified T/P ratio was moderately and positively correlated with the percentage change in the Unified Parkinson's Disease Rating Scale III score in the OFF state, the sum of cardinal motor signs, the Non-Motor Symptom Scale score, and QOL (PDQ-39).

Conclusion: Preoperative PD motor subtyping can be used as an indicator of the short-term outcomes of STN DBS in PD patients.

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DBS前改良震颤/姿势不稳定性和步态困难评分比作为帕金森病丘脑下核DBS短期预后的指标。

目的：帕金森病（PD）脑深部电刺激后运动和非运动特征的结局因其亚型而异。我们使用改进的震颤/PIGD比率测试术前运动亚型是否可以指示STN-DBS的短期运动、非运动和生活质量（QOL）结果。方法：本前瞻性研究对39例连续STN-DBS患者进行术前off状态评估，并采用震颤与PIGD评分（T/P比）进行分型。术后6个月重新评估患者刺激ON-Drug - OFF状态，计算运动、非运动和生活质量评分（PDQ39）变化百分比。结果：改良后的T/P比值与UPDRS III评分、主要运动体征、非运动症状量表（NMSS）和生活质量（PDQ39）的百分比变化呈中等正相关。结论：术前PD运动分型可作为STN-DBS短期预后的指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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