Investigating the Impact of Sumac Capsules on Postpartum Bleeding among Women at Risk of Bleeding: a three-blind randomized clinical trial.

IF 1.2 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Pharmacopuncture Pub Date : 2024-12-31 DOI:10.3831/KPI.2024.27.4.287

Mahsa Payranj, Maryam Moradi, Hassan Rakhshandeh, Vahid Ghavami, Seyed Mostafa Moshirian Farahi, Maliheh Gharaee Najafabadi, Morvarid Irani, Azin Niazi

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引用次数: 0

Abstract

Objectives: Postpartum hemorrhage is a leading cause of maternal mortality worldwide. Emerging evidence suggests that the sumac plant possesses astringent and anti-inflammatory properties that may help reduce menstrual bleeding. Therefore, this study aimed to determine the effect of sumac capsules on postpartum bleeding among women at risk of excessive bleeding.

Methods: This randomized, triple-blind clinical trial was conducted in 2022-2023. Participants were 72 women who were referred for vaginal delivery to the 9th Day Hospital in Torbat Heydariyeh city, Iran. Participants were randomly divided into two groups immediately after delivery, the placebo group received routine care. The intervention group, in addition to routine care, received two oral capsules of 500 mg sumac immediately after the expulsion of the placenta and fetal membranes, as well as two hours later. The amount of bleeding was measured using plastic bags for blood collection, which were weighed along with the sheets and pads used at hours 1, 2, 3, and 4 postpartum. Data analysis was performed using SPSS version 27, and statistical significance was set at p < 0.05. 65 women completed the study.

Results: The sumac group exhibited lower mean bleeding volumes than the placebo group at all measured time points (first, second, third, and fourth hours after delivery). The independent t-test analysis revealed significant differences between the two groups' bleeding volume at the end of the first hour (p = 0.013), second hour (p < 0.001), third hour (p < 0.001), and fourth hour (p < 0.001); that was less in sumac group. Overall, the sumac group demonstrated a significantly lower mean total bleeding volume in the first four hours after delivery (215.78 ± 16.92 cc) compared to the placebo group (261.51 ± 17.258 cc) (p < 0.001).

Conclusion: Sumac capsules can be considered as a potentially effective and safe intervention for reducing postpartum bleeding among women at risk.

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研究漆树胶囊对出血风险妇女产后出血的影响：一项三盲随机临床试验。

目的：产后出血是全世界孕产妇死亡的主要原因。新出现的证据表明，漆树植物具有收敛和抗炎的特性，可能有助于减少月经出血。因此，本研究旨在确定漆树胶囊对有出血过多风险妇女产后出血的影响。方法：该随机、三盲临床试验于2022-2023年进行。参与者是72名妇女，她们被转诊到伊朗Torbat Heydariyeh市的第九天医院进行阴道分娩。参与者在分娩后立即随机分为两组，安慰剂组接受常规护理。干预组在常规护理的基础上，在胎盘和胎膜排出后立即和2小时后口服两粒500毫克漆树甙胶囊。在产后1、2、3和4小时，用塑料袋和床单、卫生巾一起称重，用于采血，测量出血量。数据分析采用SPSS 27版，p < 0.05为差异有统计学意义。65名女性完成了这项研究。结果：漆树组在所有测量时间点（分娩后第一、第二、第三和第四小时）的平均出血量均低于安慰剂组。独立t检验分析显示，两组患者第1小时（p = 0.013）、第2小时（p < 0.001）、第3小时（p < 0.001）、第4小时出血量差异有统计学意义（p < 0.001）；这在漆树组较少。总体而言，与安慰剂组（261.51±17.258 cc）相比，漆树组在分娩后4小时的平均总出血量（215.78±16.92 cc）显着降低（p < 0.001）。结论：漆树胶囊可以被认为是一种潜在的有效和安全的干预措施，以减少产后出血的危险妇女。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Pharmacopuncture INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

2.10

自引率

7.10%

发文量

审稿时长

10 weeks

期刊介绍： The Journal of Pharmacopuncture covers a wide range of basic and clinical science research relevant to all aspects of the biotechnology of integrated approaches using both pharmacology and acupuncture therapeutics, including research involving pharmacology, acupuncture studies and pharmacopuncture studies. The subjects are mainly divided into three categories: pharmacology (applied phytomedicine, plant sciences, pharmacology, toxicology, medicinal plants, traditional medicines, herbal medicine, Sasang constitutional medicine, herbal formulae, foods, agricultural technologies, naturopathy, etc.), acupuncture (acupressure, electroacupuncture, laser acupuncture, moxibustion, cupping, etc.), and pharmacopuncture (aqua-acupuncture, meridian pharmacopuncture, eight-principles pharmacopuncture, animal-based pharmacopuncture, mountain ginseng pharmacopuncture, bee venom therapy, needle embedding therapy, implant therapy, etc.). Other categories include chuna treatment, veterinary acupuncture and related animal studies, alternative medicines for treating cancer and cancer-related symptoms, etc. Broader topical coverage on the effects of acupuncture, the medical plants used in traditional and alternative medicine, pharmacological action and other related modalities, such as anthroposophy, homeopathy, ayurveda, bioelectromagnetic therapy, chiropractic, neural therapy and meditation, can be considered to be within the journal’s scope if based on acupoints and meridians. Submissions of original articles, review articles, systematic reviews, case reports, brief reports, opinions, commentaries, medical lectures, letters to the editor, photo-essays, technical notes, and book reviews are encouraged. Providing free access to the full text of all current and archived articles on its website (www.journal.ac), also searchable through a Google Scholar search.