Effects of Vitamin D Supplementation on Serum 25-Hydroxy Cholecalciferol in Inflammatory Bowel Diseases: A Meta-Analysis of Randomized Clinical Trials.

IF 1.7 Q2 MEDICINE, GENERAL & INTERNAL
International Journal of Preventive Medicine Pub Date : 2024-11-28 eCollection Date: 2024-01-01 DOI:10.4103/ijpvm.ijpvm_133_23
Reza Ramezani, Parivash Ghorbaninejad, Masoumeh Eslahi, Leila Sheikhi, Fatemeh Abbasi, Mohaddeseh Hasanzadeh, Saba Mohammadpour, Alireza Milajerdi
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引用次数: 0

Abstract

Background: Earlier studies about the influence of vitamin D (Vit D) supplementation on patients with inflammatory bowel disease (IBD) reported inconsistent results. Current comprehensive systematic review and meta-analysis was conducted to assess the effect of Vit D supplementation on clinical and subclinical factors in patients with IBD.

Methods: PubMed, Scopus, and Web of Science databases were searched for relevant randomized controlled trials (RCTs) on the effect of Vit D supplementation in IBD patients, published up to March 2023. Data were analyzed by the random-effect model. Heterogeneity was assessed by Cochran's Q test and I-square (I 2) statistic. The mean differences (MDs) were calculated as the summary effect size.

Results: We included nine related articles, and our findings indicated that vitamin D administration increased serum vitamin D levels compared to placebo (weighted mean difference (WMD): 12.08; 95% confidence interval (95% CI): 9.06, 15.09; I 2 = 97.01%; P < 0.001) in IBD patients. However, it had no significant influence on disease activity (standardized mean difference (SMD): 0.27; 95% CI: -0.42, 0.95; I2 = 91.7%; P < 0.001) or serum levels of C-reactive protein (CRP) (WMD: -1.42; 95% CI: -3.90, 1.06; I2 = 41.9%; P = 0.262).

Conclusions: Current meta-analysis showed a significant effect of Vit D supplementation on increasing serum cholecalciferol. However, no significant effects of Vit D supplementation on the disease activity and serum levels of CRP were seen. Further studies are needed to expand current knowledge in this issue and found a significant increment in serum 25-hydroxy cholecalciferol concentrations following Vit D supplementation in IBD patients.

补充维生素D对炎症性肠病患者血清25-羟基胆骨化醇的影响:随机临床试验的荟萃分析
背景:早期关于补充维生素D (Vit D)对炎症性肠病(IBD)患者影响的研究报道了不一致的结果。目前进行了全面的系统回顾和荟萃分析,以评估维生素D补充对IBD患者临床和亚临床因素的影响。方法:检索PubMed、Scopus和Web of Science数据库,检索截至2023年3月发表的有关补充维生素D对IBD患者影响的相关随机对照试验(rct)。数据采用随机效应模型进行分析。异质性采用Cochran’s Q检验和I-square (i2)统计量进行评估。计算平均差异(MDs)作为总效应大小。结果:我们纳入了9篇相关文章,我们的研究结果表明,与安慰剂相比,服用维生素D可提高血清维生素D水平(加权平均差(WMD): 12.08;95%置信区间(95% CI): 9.06, 15.09;I 2 = 97.01%;P < 0.001)。但对疾病活动性无显著影响(标准化平均差值(SMD): 0.27;95% ci: -0.42, 0.95;I2 = 91.7%;P < 0.001)或血清c反应蛋白(CRP)水平(WMD: -1.42;95% ci: -3.90, 1.06;I2 = 41.9%;P = 0.262)。结论:当前的荟萃分析显示维生素D补充对增加血清胆钙化醇有显著作用。然而,维生素D补充对疾病活动性和血清CRP水平没有显著影响。需要进一步的研究来扩展这方面的现有知识,并发现IBD患者补充维生素D后血清25-羟基胆骨化醇浓度显著增加。
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来源期刊
International Journal of Preventive Medicine
International Journal of Preventive Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
4.80%
发文量
107
期刊介绍: International Journal of Preventive Medicine, a publication of Isfahan University of Medical Sciences, is a peer-reviewed online journal with Continuous print on demand compilation of issues published. The journal’s full text is available online at http://www.ijpvmjournal.net. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository. The journal will cover technical and clinical studies related to health, ethical and social issues in field of Preventive Medicine. Articles with clinical interest and implications will be given preference.
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