An mpox quadrivalent mRNA vaccine elicits sustained and protective immunity in mice against lethal vaccinia virus challenge.

IF 8.4 2区医学 Q1 IMMUNOLOGY

Emerging Microbes & Infections Pub Date : 2025-12-01 Epub Date: 2025-01-22 DOI:10.1080/22221751.2024.2447619

Entao Li, Qiyuan Yang, Wenyu Xie, Qizan Gong, Xiaoping Guo, Jinge Zhou, Jiachen Zhang, Xia Chuai, Yucai Wang, Sandra Chiu

引用次数: 0

Abstract

Assessing the long-term efficacy of MPXV vaccine candidates is crucial for the global response to the ongoing mpox epidemic. Built upon our previous study of the mpox quadrivalent mRNA vaccine, herein we reported that MPXV-1103 could elicit sustained humoral and cellular immunity in mice, including the induction of MPXV A35/B6/A29/M1-specific IgG antibodies, VACV neutralizing antibodies and activated cytotoxic CD8⁺T cells, which provides 100% protection against lethal VACV challenge even at 280 days after the first vaccination. Our results provide critical insights for orthopoxvirus vaccine development.

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m痘四价mRNA疫苗可诱导小鼠对致命痘苗病毒的持续和保护性免疫。

评估MPXV候选疫苗的长期疗效对于全球应对持续的m痘流行至关重要。基于我们之前对m痘四价mRNA疫苗的研究，本文中我们报道了MPXV-1103可以在小鼠中引发持续的体液和细胞免疫，包括诱导MPXV A35/B6/A29/ m1特异性IgG抗体，VACV中和抗体和活化的细胞毒性CD8+T细胞，即使在第一次接种后280天也能提供100%的保护，抵抗致命的VACV攻击。我们的研究结果为正痘病毒疫苗的开发提供了重要的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Emerging Microbes & Infections IMMUNOLOGY-MICROBIOLOGY

CiteScore

26.20

自引率

2.30%

发文量

276

审稿时长

20 weeks

期刊介绍： Emerging Microbes & Infections is a peer-reviewed, open-access journal dedicated to publishing research at the intersection of emerging immunology and microbiology viruses. The journal's mission is to share information on microbes and infections, particularly those gaining significance in both biological and clinical realms due to increased pathogenic frequency. Emerging Microbes & Infections is committed to bridging the scientific gap between developed and developing countries. This journal addresses topics of critical biological and clinical importance, including but not limited to: - Epidemic surveillance - Clinical manifestations - Diagnosis and management - Cellular and molecular pathogenesis - Innate and acquired immune responses between emerging microbes and their hosts - Drug discovery - Vaccine development research Emerging Microbes & Infections invites submissions of original research articles, review articles, letters, and commentaries, fostering a platform for the dissemination of impactful research in the field.