Anti-biofouling marine diterpenoids from Okinawan soft corals.

IF 2.6 3区生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biofouling Pub Date : 2025-01-02 DOI:10.1080/08927014.2024.2443029

Shinnosuke Ishigami, Ryoma Nakagawa, Fumiya Yagi, Hikaru Takada, Ayano Suzuki, Takashi Kamada, Kazumi Nimura, Iori Oshima, Chin-Soon Phan, Takahiro Ishii

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引用次数: 0

Abstract

Soft corals produce a diverse range of natural products with pharmaceutical potential, such as antiproliferative and anti-inflammatory effects. The Alcyoniidae family, particularly the genera Sarcophyton and Sinularia, is rich in bioactive terpenoids. However, despite extensive research, their anti-biofouling properties against the mussel Mytilus galloprovincialis remain underexplored. This study investigates these compounds as potential eco-friendly antifouling agents. A new cembrane-type diterpenoid, 11,12-epoxycembrene A (1), and 15 known compounds were isolated from three soft corals distributed in Okinawa, Japan. The chemical structures of these secondary metabolites were elucidated based on spectroscopic analysis. Moreover, an anti-biofouling assay of potential anti-biofouling agents against M. galloprovincialis was performed and their toxicities were assessed by means of the brine shrimp mortality test. In conclusion, this study identifies new and known bioactive compounds from soft corals, introduces an improved anti-biofouling assay, and highlights the potential of dimethylamine-containing diterpenes as environmentally friendly antifouling agents.

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冲绳软珊瑚中抗生物污染的海洋二萜。

软珊瑚可生产多种具有药用潜力的天然产品，例如抗增殖和抗炎作用。藻藻科，特别是藻藻属和藻藻属，富含生物活性萜类。然而，尽管进行了广泛的研究，但它们对贻贝（Mytilus galloprovincialis）的抗生物污染性能仍未得到充分的研究。本研究探讨了这些化合物作为潜在的生态友好型防污剂。从日本冲绳三种软珊瑚中分离到一种新的膜型二萜类化合物11,12-环氧树脂烯A(1)和15个已知化合物。这些次生代谢物的化学结构通过光谱分析得到了明确。此外，还对潜在的防垢剂进行了防垢试验，并通过盐水对虾死亡率试验对其毒性进行了评价。总之，本研究从软珊瑚中鉴定出新的和已知的生物活性化合物，介绍了一种改进的抗生物污染测定方法，并强调了含二甲胺的二萜作为环保防污剂的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biofouling 生物-海洋与淡水生物学

CiteScore

5.00

自引率

7.40%

发文量

审稿时长

1.7 months

期刊介绍： Biofouling is an international, peer-reviewed, multi-discliplinary journal which publishes original articles and mini-reviews and provides a forum for publication of pure and applied work on protein, microbial, fungal, plant and animal fouling and its control, as well as studies of all kinds on biofilms and bioadhesion. Papers may be based on studies relating to characterisation, attachment, growth and control on any natural (living) or man-made surface in the freshwater, marine or aerial environments, including fouling, biofilms and bioadhesion in the medical, dental, and industrial context. Specific areas of interest include antifouling technologies and coatings including transmission of invasive species, antimicrobial agents, biological interfaces, biomaterials, microbiologically influenced corrosion, membrane biofouling, food industry biofilms, biofilm based diseases and indwelling biomedical devices as substrata for fouling and biofilm growth, including papers based on clinically-relevant work using models that mimic the realistic environment in which they are intended to be used.