Cardiac cells and mesenchymal stem cells derived extracellular vesicles: a potential therapeutic strategy for myocardial infarction.

IF 2.8 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Frontiers in Cardiovascular Medicine Pub Date : 2024-12-18 eCollection Date: 2024-01-01 DOI:10.3389/fcvm.2024.1493290
Dan Qin, Xiaobo Wang, Jun Pu, Houxiang Hu
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引用次数: 0

Abstract

Despite improvements in clinical outcomes of acute myocardial infarction (AMI), mortality rates remain high, indicating the need for further understanding of the pathogenesis and developing more effective cardiac protection strategies. Extracellular vesicles (EVs) carry proteins and noncoding RNAs (ncRNAs) derived from different cardiac cell populations, mainly including cardiomyocytes, endothelial cells, endothelial progenitor cells, cardiac progenitor cells, cardiosphere-derived cells, immune cells, fibroblasts and cardiac telocytes have vital roles under both physiological and pathological process such as myocardial infarction (MI). The content of EVs can also indicate the status of their parental cells and serve as a biomarker for monitoring the risk of cardiac injury. Examining these vesicles can offer fresh perspectives on the development of MI and assist in creating innovative treatments. Additionally, mesenchymal stem cells (MSCs) (MSC-EVs) derived EVs have been shown to have significant potential in cardiac regeneration. In this review, we will discuss the current understanding of the role of EVs in cardiac communication, with a focus on the perspectives of EVs from various cardiac cells and MSCs for their potential uses as cardiac therapies after MI.

心肌细胞和间充质干细胞衍生的细胞外囊泡:心肌梗死的潜在治疗策略。
尽管急性心肌梗死(AMI)的临床预后有所改善,但死亡率仍然很高,这表明需要进一步了解其发病机制并制定更有效的心脏保护策略。细胞外囊泡(Extracellular vesicles, EVs)携带来自不同心脏细胞群的蛋白质和非编码rna (ncRNAs),主要包括心肌细胞、内皮细胞、内皮祖细胞、心脏祖细胞、心球源性细胞、免疫细胞、成纤维细胞和心脏远端细胞,在心肌梗死(MI)等生理和病理过程中都起着重要作用。EVs的含量也可以指示亲本细胞的状态,并作为监测心脏损伤风险的生物标志物。检查这些囊泡可以为心肌梗死的发展提供新的视角,并有助于创造创新的治疗方法。此外,间充质干细胞(MSCs) (msc - ev)衍生的ev已被证明在心脏再生中具有显著的潜力。在这篇综述中,我们将讨论目前对ev在心脏通讯中的作用的理解,重点讨论来自各种心肌细胞和间充质干细胞的ev在心肌梗死后心脏治疗中的潜在应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Frontiers in Cardiovascular Medicine
Frontiers in Cardiovascular Medicine Medicine-Cardiology and Cardiovascular Medicine
CiteScore
3.80
自引率
11.10%
发文量
3529
审稿时长
14 weeks
期刊介绍: Frontiers? Which frontiers? Where exactly are the frontiers of cardiovascular medicine? And who should be defining these frontiers? At Frontiers in Cardiovascular Medicine we believe it is worth being curious to foresee and explore beyond the current frontiers. In other words, we would like, through the articles published by our community journal Frontiers in Cardiovascular Medicine, to anticipate the future of cardiovascular medicine, and thus better prevent cardiovascular disorders and improve therapeutic options and outcomes of our patients.
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