Novel gold nanoparticles-Schiff base electrochemical sensor for the determination of lead (II) ions in biological samples.

IF 4.8 2区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioelectrochemistry Pub Date : 2024-12-19 DOI:10.1016/j.bioelechem.2024.108886

Zahra Akbari, Khouloud Abid, Daniela Iannazzo, Morteza Montazerozohori, Giovanni Neri

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引用次数: 0

Abstract

In this investigation, a novel tetradentate Schiff base ligand, (ligand L) was synthesized using a simple chemical route assisted by triethylenetetramine with 4-dimethylaminocinnamaldehyde in ethanol. The chemical structure of the as-synthesized ligand was characterized using nuclear magnetic resonance (NMR) and UV-visible spectroscopy. This ligand was then employed to modify the working electrode of screen-printed carbon electrode (SPCE) for developing a modified L/SPCE sensor finalized to detection of lead ions (Pb²⁺). The electrochemical characteristics of the sensor were assessed by Square Wave Anodic Stripping Voltammetry technique (SWASV). To further enhance the sensitivity, gold nanoparticles (AuNps) were deposited on the surface of the working electrode for obtaining an AuNps-L/SPCE sensor. This device shows a linear response to Pb²⁺ until to 0.6 µM, a sensitivity of 897 µA µM^-1 cm^-2 and a limit of detection (LOD) of 0.38 μM. This successful strategy offers promising avenues for lead ion detection also in urine.

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新型金纳米粒子-希夫碱电化学传感器测定生物样品中铅离子。

本研究以四乙基四胺和4-二甲氨基肉桂醛为辅助剂，在乙醇中合成了一种新型的四齿席夫碱配体（配体L）。利用核磁共振（NMR）和紫外可见光谱对合成配体的化学结构进行了表征。然后利用该配体修饰丝网印刷碳电极（SPCE）的工作电极，开发出用于检测铅离子（Pb2+）的改性L/SPCE传感器。采用方波阳极溶出伏安法（SWASV）对传感器的电化学特性进行了评价。为了进一步提高灵敏度，在工作电极表面沉积了金纳米粒子（AuNps），获得了AuNps- l /SPCE传感器。该器件对Pb2+的线性响应范围为0.6µM，灵敏度为897µaµM-1 cm-2，检测限（LOD）为0.38 μM。这一成功的策略也为尿液中的铅离子检测提供了有希望的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioelectrochemistry 生物-电化学

CiteScore

9.10

自引率

6.00%

发文量

238

审稿时长

38 days

期刊介绍： An International Journal Devoted to Electrochemical Aspects of Biology and Biological Aspects of Electrochemistry Bioelectrochemistry is an international journal devoted to electrochemical principles in biology and biological aspects of electrochemistry. It publishes experimental and theoretical papers dealing with the electrochemical aspects of: • Electrified interfaces (electric double layers, adsorption, electron transfer, protein electrochemistry, basic principles of biosensors, biosensor interfaces and bio-nanosensor design and construction. • Electric and magnetic field effects (field-dependent processes, field interactions with molecules, intramolecular field effects, sensory systems for electric and magnetic fields, molecular and cellular mechanisms) • Bioenergetics and signal transduction (energy conversion, photosynthetic and visual membranes) • Biomembranes and model membranes (thermodynamics and mechanics, membrane transport, electroporation, fusion and insertion) • Electrochemical applications in medicine and biotechnology (drug delivery and gene transfer to cells and tissues, iontophoresis, skin electroporation, injury and repair). • Organization and use of arrays in-vitro and in-vivo, including as part of feedback control. • Electrochemical interrogation of biofilms as generated by microorganisms and tissue reaction associated with medical implants.